Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, 08826, Republic of Korea.
School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea.
Adv Mater. 2021 Jun;33(24):e2100425. doi: 10.1002/adma.202100425. Epub 2021 May 6.
The low delivery efficiency of light-responsive theranostic nanoparticles (NPs) to target tumor sites, particularly to brain tumors due to the blood-brain barrier, has been a critical issue in NP-based cancer treatments. Furthermore, high-energy photons that can effectively activate theranostic NPs are hardly delivered to the target region due to the strong scattering of such photons while penetrating surrounding tissues. Here, a localized delivery method of theranostic NPs and high-energy photons to the target tumor using microneedles-on-bioelectronics is presented. Two types of microneedles and flexible bioelectronics are integrated and mounted on the edge of surgical forceps. Bioresorbable microneedles containing theranostic NPs deliver the NPs into target tumors (e.g., glioblastoma, pituitary adenoma). Magnetic resonance imaging can locate the NPs. Then, light-guiding/spreading microneedles deliver high-energy photons from bioelectronics to the NPs. The high-energy photons activate the NPs to treat tumor tissues by photodynamic therapy and chemotherapy. The controlled thermal actuation by the bioelectronics accelerates the diffusion of chemo-drugs. The proposed method is demonstrated with mouse tumor models in vivo.
光响应治疗诊断纳米粒子（NPs）向肿瘤部位的递药效率低，特别是由于血脑屏障的存在，向脑肿瘤部位的递药效率更低，这一直是 NP 为基础的癌症治疗中的一个关键问题。此外，由于高能光子在穿透周围组织时会强烈散射，因此很难将其有效地递送到目标区域。在这里，提出了一种使用微针-生物电子学将治疗诊断 NPs 和高能光子靶向递送到肿瘤部位的局部递药方法。两种类型的微针和柔性生物电子学被集成并安装在手术夹具的边缘上。含有治疗诊断 NPs 的可生物降解微针将 NPs 递送到目标肿瘤（例如，神经胶质瘤、垂体腺瘤）中。磁共振成像可以定位 NPs。然后，光导/扩散微针将高能光子从生物电子学传递到 NPs。高能光子通过光动力疗法和化学疗法激活 NPs 来治疗肿瘤组织。该方法在体内小鼠肿瘤模型中得到了验证。
