Department of Chemistry, Virginia Tech Center for Drug Discovery, and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, USA.
Department of Molecular, Cellular, and Biomedical Sciences, City University of New York School of Medicine, New York, NY 10031, USA.
Chem Commun (Camb). 2021 Jun 3;57(45):5522-5525. doi: 10.1039/d1cc01309b.
A library of N-thiocarboxyanhydrides (NTAs) derived from natural amino acids with benign byproducts and controlled H2S-release kinetics is reported. Minimal acute in vitro toxicity was observed in multiple cell lines, while longer-term toxicity in cancer cells was observed, with slow-releasing donors exhibiting the greatest cytotoxic effects.
报道了一种由天然氨基酸衍生的 N-硫代羧酸酐（NTAs）库，其副产物良性且可控制 H2S 释放动力学。在多种细胞系中观察到最小的急性体外毒性，而在癌细胞中观察到长期毒性，缓慢释放供体表现出最大的细胞毒性作用。
