人类细胞与疼痛网络：改变疼痛靶点的识别和治疗开发。
Human cells and networks of pain: Transforming pain target identification and therapeutic development.
机构信息
Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Department of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St Louis, MO 63110, USA.
出版信息
Neuron. 2021 May 5;109(9):1426-1429. doi: 10.1016/j.neuron.2021.04.005.
Abstract
Chronic pain is a disabling disease with limited treatment options. While animal models have revealed important aspects of pain neurobiology, therapeutic translation of this knowledge requires our understanding of these cells and networks of pain in humans. We propose a multi-institutional collaboration to rigorously and ethically address this challenge.
摘要
慢性疼痛是一种致残性疾病，治疗选择有限。尽管动物模型揭示了疼痛神经生物学的重要方面，但这方面知识的治疗转化需要我们了解人类的这些细胞和疼痛网络。我们建议进行多机构合作，以严格和合乎道德的方式应对这一挑战。
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