Department of Endocrinology and Metabolism, First Hospital of Jilin University, Changchun, Jilin, China.
Department of Endocrinology and Metabolism, First Hospital of Jilin University, Changchun, Jilin, China.
Front Neuroendocrinol. 2021 Jul;62:100916. doi: 10.1016/j.yfrne.2021.100916. Epub 2021 May 3.
Type 2 diabetes mellitus (T2DM) is related to abnormal brain structure and function, increasing the risk of cognitive impairment and dementia. We systematically reviewed the published literature focusing on cerebral perfusion in patients with T2DM. Although no significant difference was found in global cerebral blood flow (CBF) between the T2DM group and the healthy control group, the regional cerebral perfusion in T2DM was significantly reduced in multiple locations, including the occipital lobe, domains involved in the default mode network and the cerebellum. The decline in regional CBF was associated with a wide range of cognitive disorders in T2DM, including learning, memory, attention, and executive processing, as well as visual function. In addition, diabetes-related biochemical indicators, such as glycated hemoglobin and insulin resistance, were negatively correlated with regional CBF. In general, these functional perfusion imaging studies indicate that decreased CBF in T2DM may be a potential cause of cognitive impairment.
2 型糖尿病（T2DM）与异常的脑结构和功能有关，增加了认知障碍和痴呆的风险。我们系统地回顾了已发表的文献，重点关注 T2DM 患者的脑灌注。尽管 T2DM 组和健康对照组之间的全脑血流（CBF）没有显著差异，但 T2DM 患者的多个部位，包括枕叶、默认模式网络涉及的脑区和小脑的局部脑灌注明显减少。区域性 CBF 的下降与 T2DM 患者广泛的认知障碍有关，包括学习、记忆、注意力和执行处理以及视觉功能。此外，与糖尿病相关的生化指标，如糖化血红蛋白和胰岛素抵抗，与区域性 CBF 呈负相关。总的来说，这些功能灌注成像研究表明，T2DM 中 CBF 的减少可能是认知障碍的潜在原因。
