Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr,b, Dhaka 1212, Bangladesh; Department of Neurology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr,b, Dhaka 1212, Bangladesh.
J Neuroimmunol. 2021 Jul 15;356:577590. doi: 10.1016/j.jneuroim.2021.577590. Epub 2021 Apr 28.
A 50-years old male presented with quadriplegia and paresthesia and was diagnosed as Guillain-Barré syndrome (GBS). He was found positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) six weeks prior to the onset of weakness. GBS disability score was 4. Electrophysiology showed acute inflammatory demyelinating polyradiculopathy. Anti-SARS-CoV-2 IgG was found positive. Immunological tests for Campylobacter jejuni, Zika virus, Hepatitis E virus, Herpes Simplex virus, Haemophilus influanzae and Mycoplasma pneumoniae were negative. Patient received standard dose of intravenous immunoglobulin and after six months had almost complete recovery of muscle power. This case represents possible association of SARS-CoV-2 infection and GBS with good clinical outcome.
一位 50 岁男性出现四肢瘫痪和感觉异常，并被诊断为格林-巴利综合征（GBS）。他在出现无力症状前六周被发现 SARS-CoV-2（严重急性呼吸综合征冠状病毒-2）呈阳性。GBS 残疾评分 4 分。电生理学显示急性炎症性脱髓鞘性多发性神经病。抗 SARS-CoV-2 IgG 呈阳性。空肠弯曲菌、寨卡病毒、戊型肝炎病毒、单纯疱疹病毒、流感嗜血杆菌和肺炎支原体的免疫学检测均为阴性。患者接受了标准剂量的静脉注射免疫球蛋白治疗，六个月后肌肉力量几乎完全恢复。本病例代表 SARS-CoV-2 感染与 GBS 可能存在关联，并具有良好的临床转归。
