Tawakul Abdullah Ahmad, Al-Doboke Amal Waleed, Altayyar Shahad Ali, Alsulami Seham Abdulhafith, Alfahmi Ahlam Musallam, Nooh Raghad Turki
Faculty of Medicine, Department of Medicine, Umm Al Qura University, Al-Abdia Main Campus, Makkah 21955, Saudi Arabia.
College of Medicine, Umm Al-Qura University, Al-Abdia Main Campus, Makkah 21955, Saudi Arabia.
Neurol Int. 2021 Dec 24;14(1):34-48. doi: 10.3390/neurolint14010003.
There have been several reported cases of severe acute respiratory syndrome (SARS-CoV-2) infection that were associated with an increased incidence of neurological manifestations, including Guillain-Barré syndrome (GBS). This review aims to present information on the reports of GBS associated with coronavirus disease 2019 (COVID-19) infection. Our review is retrospective work examining articles published from the 1 April 2020 to the 8 May 2021 in the English language. We used the diagnostic criteria and classification published by the National Institute of Neurological Disorders and Stroke and Brighton Collaboration. GBS is usually a postinfectious syndrome, but GBS in the COVID-19 pandemic also takes on a para-infectious profile. In the reports, the genetic factor has a role in developing GBS in some patients. In conclusion, the association between COVID-19 and GBS is not very clear. Still, one mechanism is strongly associated with COVID-19 and immune-mediated neurological complications, which is molecular mimicry between SARS-CoV-2 and human autoantigens.
已有多例严重急性呼吸综合征（SARS-CoV-2）感染报告与神经表现发病率增加相关，包括吉兰-巴雷综合征（GBS）。本综述旨在介绍与2019冠状病毒病（COVID-19）感染相关的GBS报告信息。我们的综述是一项回顾性研究，审查了2020年4月1日至2021年5月8日以英文发表的文章。我们采用了美国国立神经疾病和中风研究所及布莱顿协作组织发布的诊断标准和分类。GBS通常是一种感染后综合征，但COVID-19大流行期间的GBS也呈现出副感染特征。在报告中，遗传因素在一些患者发生GBS中起作用。总之，COVID-19与GBS之间的关联尚不清楚。不过，有一种机制与COVID-19和免疫介导的神经并发症密切相关，即SARS-CoV-2与人类自身抗原之间的分子模拟。
