Kuran Fadıl Kaan, Senadeera Sarath P D, Wang Dongdong, Hwang Ji-Yeon, Goncharova Ekaterina, Wilson Jennifer, Wamiru Antony, Wilson Brice A P, Pruett Nathanael, Du Lin, Hoang Chuong D, Beutler John A, Miski Mahmut
Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Türkiye.
Department of Pharmacognosy, Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul 34116, Türkiye.
Molecules. 2025 Apr 25;30(9):1916. doi: 10.3390/molecules30091916.
Four new sesquiterpene coumarin ethers (-) and a new phenylpropanoid compound () were isolated from a hexane extract of the roots of , the putative Anatolian ecotype of the silphion plant, in addition to nineteen previously described sesquiterpene coumarins (-) and four known phenylpropanoid derivatives (-). The structures of these compounds were elucidated by extensive spectroscopic analysis and computational studies. The cytotoxic activities of all isolated compounds were evaluated on renal, malignant pleural mesothelioma (MPM) and colon cancer cell lines. While 11 sesquiterpene coumarin derivatives showed strong-to-moderate cytotoxic activity against the UO31 renal cancer cell line, 13 compounds showed strong cytotoxic activity against the MPM cell line, and four sesquiterpene coumarin derivatives displayed moderate cytotoxic activity against the colon cancer cell line.
从疑似安纳托利亚生态型的水飞蓟植物根部的己烷提取物中，除了分离出19种先前已描述的倍半萜香豆素（-）和4种已知的苯丙素衍生物（-）之外，还分离出了4种新的倍半萜香豆素醚（-）和1种新的苯丙素化合物（）。通过广泛的光谱分析和计算研究阐明了这些化合物的结构。对所有分离出的化合物在肾癌细胞系、恶性胸膜间皮瘤（MPM）细胞系和结肠癌细胞系上进行了细胞毒性活性评估。虽然11种倍半萜香豆素衍生物对UO31肾癌细胞系表现出强至中度的细胞毒性活性，但13种化合物对MPM细胞系表现出强细胞毒性活性，并且4种倍半萜香豆素衍生物对结肠癌细胞系表现出中度细胞毒性活性。
