Department of Preventive Medicine, College of Medicine, Taizhou University, Taizhou, Zhejiang Province, China.
Department of Anatomy, College of Medicine, Jiaxing University, Jiaxing, Zhejiang Province, China.
Prim Health Care Res Dev. 2021 May 7;22:e18. doi: 10.1017/S1463423621000153.
To analyse the characteristics of the main leukocyte subsets and elucidate their distributions amongst the natural population. We wanted to determine whether leukocyte subsets are potential biomarkers to evaluate the risk of common chronic diseases.
The peripheral blood leukocyte count is a routine exam performed to detect pathogen infections. Recently, subsets of white blood cells and their homeostasis have shown strong associations with some chronic diseases. Therefore, studies aiming to discover whether the distribution of leukocyte counts and its subsets are useful for predicting health conditions are worthwhile.
This cross-sectional study analysed 10 564 residents from the basic public health service project of the Health Checkup Program performed by the BaiYun Community Health Service Center. Data on demographic information, physical measurements, medical history, and routine blood examination parameters were collected using questionnaires and health check-ups. Restricted cubic spline incorporated into logistic regression analysis was performed to evaluate the association between subsets of leukocytes and common chronic diseases.
The counts of leukocytes and their subsets in males were higher than those in females amongst all age groups, yet the percentages of lymphocytes and neutrophils did not present sex-specific differences. A low lymphocyte count and percentage were associated with old age. The neutrophil-to-lymphocyte ratio (NLR) in patients with hypertension was higher than that in the non-hypertensive population. The risk of NLR in the top quartiles was 1.17-fold higher than that in people in the lowest quartiles.
The distributions of the white blood cell count and percentage were associated with age, sex, and body mass index (BMI). In addition to the immune barrier for pathogens, the NLR or monocyte-to-lymphocyte ratio (MLR) may be potentially used to indicate the risk of some chronic non-communicable diseases. Homeostasis of subsets of leukocytes may be an important biomarker for body health conditions.
分析主要白细胞亚群的特征，并阐明其在自然人群中的分布。我们旨在确定白细胞亚群是否是评估常见慢性疾病风险的潜在生物标志物。
外周血白细胞计数是一种常规检查，用于检测病原体感染。最近，白细胞亚群及其稳态与一些慢性疾病有很强的关联。因此，研究旨在发现白细胞计数及其亚群的分布是否有助于预测健康状况是值得的。
本横断面研究分析了来自白云社区卫生服务中心进行的健康体检计划基本公共卫生服务项目的 10564 名居民。使用问卷和健康检查收集了人口统计学信息、身体测量、病史和常规血液检查参数的数据。受限立方样条纳入逻辑回归分析，以评估白细胞亚群与常见慢性疾病之间的关系。
在所有年龄段，男性的白细胞计数和其亚群计数均高于女性，但淋巴细胞和中性粒细胞的比例没有性别差异。低淋巴细胞计数和比例与年龄有关。高血压患者的中性粒细胞与淋巴细胞比值（NLR）高于非高血压人群。NLR 处于前四分位数的风险是处于最低四分位数的人的 1.17 倍。
白细胞计数和百分比的分布与年龄、性别和体重指数（BMI）有关。除了病原体的免疫屏障外，NLR 或单核细胞与淋巴细胞比值（MLR）可能被用于指示某些慢性非传染性疾病的风险。白细胞亚群的稳态可能是身体健康状况的一个重要生物标志物。
