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巨噬细胞中的固有免疫记忆

Innate Immune Memory in Macrophages.

作者信息

Maheshwari Akhil

机构信息

Founding Chairman, Global Newborn Society, Clarksville, Maryland, United States of America.

出版信息

Newborn (Clarksville). 2023 Jan-Mar;2(1):60-79. doi: 10.5005/jp-journals-11002-0058. Epub 2023 Apr 6.

DOI:10.5005/jp-journals-11002-0058
PMID:37206580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10193650/
Abstract

Macrophages have been recognized as the primary mediators of innate immunity starting from embryonic/fetal development. Macrophage-mediated defenses may not be as antigen-specific as adaptive immunity, but increasing information suggests that these responses do strengthen with repeated immunological triggers. The concept of innate memory in macrophages has been described as "trained immunity" or "innate immune memory (IIM)." As currently understood, this cellular memory is rooted in epigenetic and metabolic reprogramming. The recognition of IIM may be particularly important in the fetus and the young neonate who are yet to develop protective levels of adaptive immunity, and could even be of preventive/therapeutic importance in many disorders. There may also be a possibility of therapeutic enhancement with targeted vaccination. This article presents a review of the properties, mechanisms, and possible clinical significance of macrophage-mediated IIM.

摘要

从胚胎/胎儿发育开始，巨噬细胞就被认为是固有免疫的主要介质。巨噬细胞介导的防御可能不像适应性免疫那样具有抗原特异性，但越来越多的信息表明，这些反应会随着反复的免疫触发而增强。巨噬细胞固有记忆的概念被描述为“训练有素的免疫”或“固有免疫记忆（IIM）”。目前的理解是，这种细胞记忆源于表观遗传和代谢重编程。认识到IIM在尚未发展出保护性适应性免疫水平的胎儿和新生儿中可能尤为重要，甚至在许多疾病中可能具有预防/治疗意义。靶向疫苗接种也可能具有治疗增强的可能性。本文综述了巨噬细胞介导的IIM的特性、机制和可能的临床意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7d/10193650/7f944cda3292/nihms-1890242-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7d/10193650/f6e0f1b342b7/nihms-1890242-f0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7d/10193650/7f944cda3292/nihms-1890242-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7d/10193650/f6e0f1b342b7/nihms-1890242-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7d/10193650/df2a474518fc/nihms-1890242-f0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7d/10193650/129a3fe43054/nihms-1890242-f0005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7d/10193650/7f944cda3292/nihms-1890242-f0007.jpg

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Newborn (Clarksville). 2022 Oct-Dec;1(4):340-355. doi: 10.5005/jp-journals-11002-0044. Epub 2022 Dec 23.
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Innate Immune Memory in Monocytes and Macrophages: The Potential Therapeutic Strategies for Atherosclerosis.先天免疫记忆在单核细胞和巨噬细胞中的作用：动脉粥样硬化的潜在治疗策略。
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