Scholkmann Felix, Zohdi Hamoon, Wolf Ursula
Institute of Complementary and Integrative Medicine, University of Bern, 3012 Bern, Switzerland.
Biomedical Optics Research Laboratory, Department of Neonatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.
Brain Sci. 2022 May 3;12(5):597. doi: 10.3390/brainsci12050597.
In our previous investigations using systemic physiology augmented functional near-infrared spectroscopy (SPA-fNIRS) neuroimaging, we found larger variability between subjects in changes of cerebral hemodynamics and oxygenation induced by an intricate experimental paradigm involving colored light exposure and a cognitive task. We aimed to investigate the role the activity of the systemic physiology has on individual variations in the fNIRS data. Thirty-two healthy subjects (17 female, 15 male and age: 25.5 ± 4.3 years) were exposed to blue and red light for 9 min (colored light exposure, CLE) while performing a verbal fluency task (VFT). We found that (i), at the group level, the visual cortex showed a stronger deoxyhemoglobin concentration response during blue light exposure than during red light exposure, and (ii) this relationship was influenced by individually different baseline blood pressure values. Furthermore, we found other correlations between changes in fNIRS signals and changes in systemic physiology. Our study demonstrates the usefulness and necessity of the SPA-fNIRS approach to gain insights into the individual variability of hemodynamic responses measured with fNIRS, especially in the case of an intricate experimental paradigm (i.e., CLE-VFT) as used in our study.
在我们之前使用全身生理学增强型功能近红外光谱（SPA-fNIRS）神经成像的研究中，我们发现，在涉及彩色光暴露和认知任务的复杂实验范式所诱发的脑血流动力学和氧合变化方面，受试者之间存在更大的变异性。我们旨在研究全身生理学活动对fNIRS数据个体差异的作用。32名健康受试者（17名女性，15名男性，年龄：25.5±4.3岁）在执行语言流畅性任务（VFT）时，接受了9分钟的蓝光和红光照射（彩色光暴露，CLE）。我们发现，（i）在组水平上，视觉皮层在蓝光暴露期间比在红光暴露期间表现出更强的脱氧血红蛋白浓度反应，并且（ii）这种关系受到个体不同的基线血压值的影响。此外，我们还发现了fNIRS信号变化与全身生理学变化之间的其他相关性。我们的研究证明了SPA-fNIRS方法对于深入了解用fNIRS测量的血流动力学反应个体变异性的有用性和必要性，特别是在我们研究中使用的复杂实验范式（即CLE-VFT）的情况下。
