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短时间光照和高能量饮食导致的昼夜节律紊乱会损害 Psammomys obesus 的葡萄糖耐量并增加心脏纤维化。

Circadian disruption by short light exposure and a high energy diet impairs glucose tolerance and increases cardiac fibrosis in Psammomys obesus.

机构信息

South Australian Health & Medical Research Institute, Adelaide, Australia.

Faculty of Health and Medical Science, The University of Adelaide, Adelaide, Australia.

出版信息

Sci Rep. 2021 May 6;11(1):9673. doi: 10.1038/s41598-021-89191-7.

DOI:10.1038/s41598-021-89191-7
PMID:33958671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8102519/
Abstract

UNLABELLED

Type 2 diabetes mellitus (T2DM) increases cardiac inflammation which promotes the development of cardiac fibrosis. We sought to determine the impact of circadian disruption on the induction of hyperglycaemia, inflammation and cardiac fibrosis.

METHODS

Psammomys obesus (P. obesus) were exposed to neutral (12 h light:12 h dark) or short (5 h light:19 h dark) photoperiods and fed a low energy (LE) or high energy (HE) diet for 8 or 20 weeks. To determine daily rhythmicity, P. obesus were euthanised at 2, 8, 14, and 20 h after 'lights on'.

RESULTS

P. obesus exposed to a short photoperiod for 8 and 20 weeks had impaired glucose tolerance following oral glucose tolerance testing, compared to a neutral photoperiod exposure. This occurred with both LE and HE diets but was more pronounced with the HE diet. Short photoperiod exposure also increased myocardial perivascular fibrosis after 20 weeks on LE (51%, P < 0.05) and HE (44%, P < 0.05) diets, when compared to groups with neutral photoperiod exposure. Short photoperiod exposure caused elevations in mRNA levels of hypertrophy gene Nppa (atrial natriuretic peptide) and hypertrophy transcription factors Gata4 and Mef2c in myocardial tissue after 8 weeks.

CONCLUSION

Exposure to a short photoperiod causes impaired glucose tolerance in P. obesus that is exacerbated with HE diet and is accompanied by an induction in myocardial perivascular fibrosis.

摘要

目的

探讨昼夜节律紊乱对高血糖、炎症和心肌纤维化诱导的影响。

方法

选用沙鼠（Psammomys obesus）作为研究对象，分别暴露于正常（12 h 光照：12 h 黑暗）或短（5 h 光照：19 h 黑暗）光照周期，并给予低能量（LE）或高能量（HE）饮食 8 或 20 周。为了确定每日节律性，在光照后 2、8、14 和 20 h 处死沙鼠。

结果

与正常光照周期相比，暴露于短光照周期 8 和 20 周的沙鼠在口服葡萄糖耐量试验后出现葡萄糖耐量受损。这种情况发生在 LE 和 HE 饮食中，但在 HE 饮食中更为明显。与正常光照周期相比，LE（51%，P<0.05）和 HE（44%，P<0.05）饮食 20 周后，短光照周期暴露还增加了心肌血管周围纤维化。短光照周期暴露还导致 8 周后心肌组织中肥厚基因 Nppa（心钠肽）和肥厚转录因子 Gata4 和 Mef2c 的 mRNA 水平升高。

结论

短光照周期暴露可导致沙鼠葡萄糖耐量受损，在给予 HE 饮食时更为严重，并伴有心肌血管周围纤维化的诱导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fba6/8102519/71c2a9463337/41598_2021_89191_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fba6/8102519/07edab3d1a7c/41598_2021_89191_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fba6/8102519/73adabde9b49/41598_2021_89191_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fba6/8102519/6f64c1f2803c/41598_2021_89191_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fba6/8102519/ceaf2339c328/41598_2021_89191_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fba6/8102519/45c192278880/41598_2021_89191_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fba6/8102519/1a9cf7fe812b/41598_2021_89191_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fba6/8102519/71c2a9463337/41598_2021_89191_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fba6/8102519/07edab3d1a7c/41598_2021_89191_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fba6/8102519/73adabde9b49/41598_2021_89191_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fba6/8102519/6f64c1f2803c/41598_2021_89191_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fba6/8102519/ceaf2339c328/41598_2021_89191_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fba6/8102519/45c192278880/41598_2021_89191_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fba6/8102519/1a9cf7fe812b/41598_2021_89191_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fba6/8102519/71c2a9463337/41598_2021_89191_Fig7_HTML.jpg

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