Zhan Changqing, Wang Qiao, Liu Jie, Wang Lei, Chen Zongsheng, Pang Hongbo, Tu Jun, Ning Xianjia, Wang Jinghua, Fei Shizao
Department of Neurology, The Second People's Hospital of Wuhu, Wuhu, Anhui, People's Republic of China.
Department of Pathology, The Second People's Hospital of Wuhu, Wuhu, Anhui, People's Republic of China.
Diabetes Metab Syndr Obes. 2021 Apr 30;14:1927-1935. doi: 10.2147/DMSO.S308250. eCollection 2021.
To explore the relationship between metabolic syndrome (MetS) and cognitive impairment in a low-income and low-education population.
All residents aged ≥45 years in a low-income population in Tianjin, China, were eligible to participate in this study. The Mini-Mental State Examination (MMSE) scale was used to conduct a preliminary screening and assessment of the participants' cognitive statuses. The MMSE components are orientation, registration, attention and calculation, recall, and language.
In this population, the prevalences of MetS and cognitive impairment were 54.1% and 44.5%, respectively. In the overall population, the registration score was 0.105 points lower in the elevated triglycerides (TG) group than in the normal TG group (β, -0.105; 95% confidence interval [CI]: -0.201, -0.010; P=0.030). In men, high TG was associated with registration scores that were 0.152 points lower than those in the normal TG group (95% CI: -0.281, -0.022; P=0.022), while larger WC and lower HDL-C had positive effects on cognitive scores (all P<0.05). However, in women, there were no significant differences between cognitive scores and MetS or its components.
In this population, first, TG had a great impact on cognition, even greater than the impact of MetS on cognition. Second, the impact of MetS components on cognition was more obvious in men, and not all of the effects were negative. Therefore, the effect of MetS on cognition may need to be analyzed separately for different populations, and it may be that the effect of a single component is greater than the overall effect. When formulating prevention strategies for cognitive impairments, population differences must also be taken into consideration.
探讨低收入、低教育水平人群中代谢综合征（MetS）与认知障碍之间的关系。
中国天津低收入人群中所有年龄≥45岁的居民均符合参与本研究的条件。采用简易精神状态检查表（MMSE）量表对参与者的认知状态进行初步筛查和评估。MMSE的组成部分包括定向、记忆、注意力及计算、回忆和语言。
在该人群中，MetS和认知障碍的患病率分别为54.1%和44.5%。在总体人群中，甘油三酯（TG）升高组的记忆得分比正常TG组低0.105分（β，-0.105；95%置信区间[CI]：-0.201，-0.010；P=0.030）。在男性中，高TG与比正常TG组低0.152分的记忆得分相关（95%CI：-0.281，-0.022；P=0.022），而腰围较大和高密度脂蛋白胆固醇（HDL-C）较低对认知得分有积极影响（所有P<0.05）。然而，在女性中，认知得分与MetS或其组成部分之间无显著差异。
在该人群中，首先，TG对认知的影响很大，甚至大于MetS对认知的影响。其次，MetS组成部分对认知的影响在男性中更为明显，且并非所有影响都是负面的。因此，可能需要针对不同人群分别分析MetS对认知的影响，且单个组成部分的影响可能大于整体影响。在制定认知障碍预防策略时，也必须考虑人群差异。
