Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Am J Trop Med Hyg. 2024 Jul 16;111(3):535-539. doi: 10.4269/ajtmh.23-0358. Print 2024 Sep 4.
Tuberculosis (TB) can cause significant morbidity and mortality among solid organ transplant (SOT) recipients, including disseminated disease. Most TB cases after SOT occur in kidney transplant recipients, although data about TB in this population are sparse. Tuberculosis may present atypically in immunocompromised patients, underscoring why physicians must maintain high clinical suspicion when pertinent epidemiological risk factors are present, including birth or former residence in a country with endemic TB. We describe a unique case of disseminated TB in a 54-year-old Filipino woman who developed central nervous system tuberculoma, Pott's disease, chorioretinitis, and a perinephric fluid collection after kidney transplantation. Despite being a preventable and curable disease, TB remains a relevant and challenging infection with complex diagnostic and treatment guidelines.
结核病（TB）可导致实体器官移植（SOT）受者发生重大发病率和死亡率，包括播散性疾病。尽管有关该人群中结核病的数据很少，但 SOT 后大多数 TB 病例发生在肾移植受者中。结核病在免疫功能低下的患者中可能表现不典型，这凸显了为什么医生在存在相关的流行病学危险因素时，包括在结核病流行的国家出生或居住过，必须保持高度的临床怀疑。我们描述了一名 54 岁菲律宾女性的独特播散性结核病病例，她在肾移植后发生中枢神经系统结核瘤、波特氏病、脉络膜视网膜炎和肾周积液。尽管结核病是一种可预防和可治愈的疾病，但它仍然是一种具有挑战性的相关感染，其诊断和治疗指南复杂。
