体内脑谷胱甘肽在老年时较高，与活动能力相关。
In Vivo Brain Glutathione is Higher in Older Age and Correlates with Mobility.
机构信息
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32603, USA.
Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
出版信息
Cereb Cortex. 2021 Aug 26;31(10):4576-4594. doi: 10.1093/cercor/bhab107.
Brain markers of oxidative damage increase with advancing age. In response, brain antioxidant levels may also increase with age, although this has not been well investigated. Here, we used edited magnetic resonance spectroscopy to quantify endogenous levels of glutathione (GSH, one of the most abundant brain antioxidants) in 37 young [mean: 21.8 (2.5) years; 19 female] and 23 older adults [mean: 72.8 (8.9) years; 19 female]. Accounting for age-related atrophy, we identified higher frontal and sensorimotor GSH levels for the older compared with the younger adults. For the older adults only, higher sensorimotor (but not frontal) GSH was correlated with poorer balance and gait. This suggests a regionally specific relationship between higher brain oxidative stress levels and motor performance declines with age. We suggest these findings reflect an upregulation of GSH in response to increasing brain oxidative stress with normal aging. Together, these results provide insight into age differences in brain antioxidant levels and implications for motor function.
大脑氧化损伤标志物随年龄增长而增加。作为应对，大脑抗氧化剂水平可能也会随年龄增长而增加，但这一点尚未得到充分研究。在这里，我们使用编辑磁共振波谱技术，对 37 名年轻成年人（平均年龄 21.8（2.5）岁，女性 19 名）和 23 名老年成年人（平均年龄 72.8（8.9）岁，女性 19 名）大脑内源性谷胱甘肽（GSH，大脑中最丰富的抗氧化剂之一）水平进行了定量。在考虑到与年龄相关的萎缩后，我们发现老年成年人的额部和感觉运动区 GSH 水平高于年轻成年人。仅在老年成年人中，感觉运动区（而非额部）GSH 水平越高，平衡和步态越差。这表明大脑氧化应激水平升高与运动表现随年龄下降之间存在特定区域关系。我们认为这些发现反映了 GSH 的上调，以应对正常衰老过程中大脑氧化应激的增加。这些结果共同提供了对大脑抗氧化剂水平随年龄差异的深入了解，并对运动功能具有启示意义。
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