Brookwell R, Hunt F A
Cytogenetics Department, N. J. Nicolaides & Partners, Brisbane, Australia.
Cancer Genet Cytogenet. 1988 Aug;34(1):47-52. doi: 10.1016/0165-4608(88)90167-7.
A patient suffering from refractory anemia with excess blasts in transformation had four different bone marrow karyotypes. These were 46,XY; 45,X,-Y; 45,X,-Y, 5q-,19q+; and 43,X,-Y,-9,-17,5q-,+dmin. The most plausible explanation for this is proposed to be formation of a homogeneously staining region on chromosome #19, followed by its breakdown into double minutes.
一名患有转化型原始细胞过多的难治性贫血患者有四种不同的骨髓核型。分别为46,XY；45,X,-Y；45,X,-Y,5q-,19q+；以及43,X,-Y,-9,-17,5q-,+dmin。对此最合理的解释是19号染色体上形成了一个均匀染色区，随后其分解成双微体。
