Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Department of Interventional Medical, Zhuhai People's Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai 519000, China.
Nanoscale. 2021 May 20;13(19):8817-8836. doi: 10.1039/d1nr01268a.
Transcatheter arterial chemoembolization (TACE) has become one of the preferred choices for advanced liver cancer patients. Current clinically used microsphere embolic agents, such as PVA, gelatin, and alginate microspheres, have limited therapeutic efficacy and lack the function of real-time imaging. In this work, we fabricated magnetic liquid metal nanoparticle (Fe@EGaIn NP) loaded calcium alginate (CA) microspheres (denoted as Fe@EGaIn/CA microspheres), which integrate CT/MR dual-modality imaging and photothermal/photodynamic functions of the Fe@EGaIn NP core, as well as embolization and drug-loading functions of CA microspheres. Namely, such nano-in-micro spheres can be used as fully flexible theranostic agents to achieve smart-chemoembolization. It has been confirmed by in vitro and in vivo experiments that Fe@EGaIn/CA microspheres have advantageous morphology, favorable biocompatibility, splendid versatility, and advanced embolic efficacy. Benefiting from these properties, excellent therapeutic efficiency was achieved with a tumor growth-inhibiting value of 100% in tumor-bearing rabbits. As a novel microsphere embolic agent with promising therapeutic efficacy and diagnostic capability, Fe@EGaIn/CA microspheres have shown potential applications in clinical transcatheter arterial chemoembolization. And the preparation strategy presented here provides a generalized paradigm for achieving multifunctional and fully flexible theranostics.
经导管动脉化疗栓塞（TACE）已成为晚期肝癌患者的首选治疗方法之一。目前临床应用的微球栓塞剂如聚乙烯醇（PVA）、明胶和海藻酸钠微球等，治疗效果有限，缺乏实时成像功能。在本工作中，我们制备了负载磁性液态金属纳米颗粒（Fe@EGaIn NP）的海藻酸钠（CA）微球（记为 Fe@EGaIn/CA 微球），其集成了 Fe@EGaIn NP 核的 CT/MR 双模态成像和光热/光动力功能，以及 CA 微球的栓塞和载药功能。即，这种纳米-微米杂化球可作为完全灵活的治疗诊断一体化试剂，实现智能化疗栓塞。体外和体内实验证实，Fe@EGaIn/CA 微球具有有利的形态、良好的生物相容性、出色的多功能性和先进的栓塞效果。由于这些特性，在荷瘤兔中实现了 100%的肿瘤生长抑制，达到了优异的治疗效果。作为一种具有潜在治疗效果和诊断能力的新型微球栓塞剂，Fe@EGaIn/CA 微球在临床经导管动脉化疗栓塞中显示出了应用潜力。并且，所提出的制备策略为实现多功能和完全灵活的治疗诊断一体化提供了一种通用范例。
