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炎症性肠病患者中风风险增加：一项遵循PRISMA标准的荟萃分析。

Increased risk of stroke among patients with inflammatory bowel disease: A PRISMA-compliant meta-analysis.

作者信息

Chen Yao, Wang Xiang

机构信息

Department of Internal Medicine, Hospital of Nanjing University of Science and Technology, Nanjing, China.

Department of Ultrasound, The Third Affiliated Hospital of Chongqing Medical University (Gener Hospital), Chongqing, China.

出版信息

Brain Behav. 2021 Jun;11(6):e02159. doi: 10.1002/brb3.2159. Epub 2021 May 7.

DOI:10.1002/brb3.2159
PMID:33960728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8213927/
Abstract

BACKGROUND

Previous studies on the association between inflammatory bowel disease (IBD) and stroke showed conflicting results.

METHODS

Articles published before July 2020 were searched in databases (PubMed, Web of Science, Medline, EMBASE, and Google Scholar). We computed all multivariate odds ratios (ORs) or relative risks (RRs) and 95% confidence intervals (CI) by using STATA 12.0 software.

RESULTS

The meta-analysis indicated that IBD was associated with an elevated risk of stroke (OR/RR = 1.21, 95% CI 1.08 to 1.34, I  = 83.6%, p < .001). In addition, both Crohn's disease (CD) and ulcerative colitis (UC) were associated with a higher risk of stroke (CD: OR/RR = 1.25, 95% CI 1.03 to 1.52, I  = 86.1%, p < .001; UC: OR/RR = 1.09, 95% CI 1.04 to 1.15, I  = 54.7%, p = .051). Subgroup study showed that IBD was associated with a higher risk of stroke in cohort studies (RR = 1.21, 95% CI 1.08 to 1.36, I  = 85.0%, p < .001). Subgroup study showed that IBD was related to an elevated risk of stroke in both Caucasian and Asian groups (Caucasian group: OR/RR = 1.13, 95% CI 1.05 to 1.23, I  = 44.6%, p = .094; Asian group: OR/RR =1.36, 95% CI 1.07 to 1.74, I  = 92.5%, p < .001).

CONCLUSION

IBD is a risk factor for stroke. More high-quality large-sample epidemiologic studies about the relationship between IBD and stroke should be further conducted.

摘要

背景

先前关于炎症性肠病（IBD）与中风之间关联的研究结果相互矛盾。

方法

在数据库（PubMed、Web of Science、Medline、EMBASE和谷歌学术）中检索2020年7月之前发表的文章。我们使用STATA 12.0软件计算所有多变量优势比（OR）或相对风险（RR）以及95%置信区间（CI）。

结果

荟萃分析表明，IBD与中风风险升高相关（OR/RR = 1.21，95% CI为1.08至1.34，I² = 83.6%，p <.001）。此外，克罗恩病（CD）和溃疡性结肠炎（UC）均与中风风险较高相关（CD：OR/RR = 1.25，95% CI为1.03至1.52，I² = 86.1%，p <.001；UC：OR/RR = 1.09，95% CI为1.04至1.15，I² = 54.7%，p = 0.051）。亚组研究表明，在队列研究中IBD与中风风险较高相关（RR = 1.21，95% CI为1.08至1.36，I² = 85.0%，p <.001）。亚组研究表明，在白种人和亚洲人群中IBD均与中风风险升高相关（白种人群：OR/RR = 1.13，95% CI为1.05至1.23，I² = 44.6%，p = 0.094；亚洲人群：OR/RR = 1.36，95% CI为1.07至1.74，I² = 92.5%，p <.001）。

结论

IBD是中风的一个风险因素。应进一步开展更多关于IBD与中风关系的高质量大样本流行病学研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e8/8213927/19aab585c51e/BRB3-11-e02159-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e8/8213927/8c9475667a44/BRB3-11-e02159-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e8/8213927/1e4dbf72bae7/BRB3-11-e02159-g007.jpg
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