Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Eur J Pharmacol. 2021 Jul 15;903:174147. doi: 10.1016/j.ejphar.2021.174147. Epub 2021 May 5.
CD44 is a cell surface adhesion molecule, which is overexpressed on cancer stem cells. The interaction of CD44 with hyaluronan is responsible for tumor development, metastasis, and expression of the chemoresistant phenotype. The overexpression of CD44 impedes the cytotoxic effect of chemotherapy medications in various cancers. Therefore, the high expression of CD44 is associated with a poor prognosis in affected patients. This high expression of CD44 in various cancers has provided an ample opportunity for the treatment of patients with chemoresistant malignancy. This review aims to demonstrate the various cross-talk between CD44 and intracellular and extracellular factors and highlight its role in developing chemoresistant tumors in some troublesome cancers.
CD44 是一种细胞表面黏附分子，在肿瘤干细胞中过表达。CD44 与透明质酸的相互作用是肿瘤发生、转移和表达化疗耐药表型的原因。CD44 的过表达会阻碍各种癌症中化疗药物的细胞毒性作用。因此，CD44 的高表达与受影响患者的预后不良相关。在各种癌症中 CD44 的高表达为治疗耐药性恶性肿瘤的患者提供了充分的机会。本综述旨在展示 CD44 与细胞内和细胞外因素之间的各种相互作用，并强调其在某些棘手癌症中形成化疗耐药肿瘤的作用。
