Think Healthy Group, Inc; Department of Nutrition and Food Studies, George Mason University, Washington, DC.
Wuqu' Kawoq/Maya Health Alliance; Brigham and Women's Hospital, Tecpán, Chimaltenango, Guatemala, Central America.
J Acad Nutr Diet. 2022 Feb;122(2):432-444. doi: 10.1016/j.jand.2021.03.015. Epub 2021 May 4.
Adequate nutrition during the complementary feeding period is critical for optimal child growth and development and for promoting long-term educational attainment and economic potential. To prioritize limited public health resources, there is a need for studies that rigorously assess the influence of multicomponent integrated nutrition interventions in children younger than age 2 years in different contexts. This study aimed to describe the rationale and protocol for the Saqmolo' Project using the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guidelines. The Saqmolo' (ie, "egg" in the Mayan language, Kaqchiquel) Project is an individually randomized, partially blinded, controlled comparative effectiveness trial to evaluate the influence of adding delivery of a single whole egg per day to local standard nutrition care (ie, growth monitoring, medical care, deworming medication, multiple micronutrient powders for point-of-use food fortification [chispitas], and individualized complementary and responsive feeding education for caregivers) for 6 months, compared with the local standard nutrition care package alone, on child development, growth, and diet quality measures in rural indigenous Mayan infants aged 6 to 9 months at baseline (N = 1,200). The study is being executed in partnership with the Wuqu' Kawoq/Maya Health Alliance, a primary health care organization located in central Guatemala. Primary outcomes for this study are changes in global development scores, assessed using the Guide for Monitoring Global Development and the Caregiver Reported Child Development Instruments. Secondary outcomes include changes in infant hemoglobin, anthropometric measures (including z scores for weight for age, length for age, weight for length, and head circumference for age), and diet quality as measured using the World Health Organization's infant and young child feeding indicators. The results of the Saqmolo' Project may help to inform public health decision making regarding resource allocation for effective nutrition interventions during the complementary feeding period.
在补充喂养期提供充足的营养对于儿童最佳生长发育以及促进长期教育成就和经济潜力至关重要。为了优先利用有限的公共卫生资源，需要开展研究，严格评估在不同背景下，针对年龄小于 2 岁的儿童实施多组分综合营养干预的影响。本研究旨在根据标准干预试验报告规范（SPIRIT）指南，描述 Saqmolo' 项目的原理和方案。Saqmolo'（即玛雅语 Kaqchiquel 中的“鸡蛋”）项目是一项个体随机、部分盲法、对照比较有效性试验，旨在评估在当地标准营养护理（即生长监测、医疗保健、驱虫药物、用于现场食物强化的多种微量营养素粉末[chispitas]和针对照顾者的个性化补充和响应式喂养教育）中，每天添加一个全蛋与仅接受当地标准营养护理套餐相比，对农村土著玛雅婴儿（6-9 月龄，基线时共 1200 名）的儿童发育、生长和饮食质量指标的影响。该研究是与 Wuqu' Kawoq/Maya 健康联盟合作开展的，该组织是一个位于危地马拉中部的初级保健组织。本研究的主要结局是使用全球发育监测指南和照顾者报告儿童发育工具评估的全球发育评分的变化。次要结局包括婴儿血红蛋白、人体测量指标（包括体重与年龄、长度与年龄、体重与长度和头围与年龄的 z 评分）和饮食质量的变化，饮食质量通过世界卫生组织的婴幼儿喂养指标来衡量。Saqmolo' 项目的结果可能有助于为补充喂养期的有效营养干预提供公共卫生决策依据。
