Recurrent Pregnancy Loss Unit, Capital Region, Copenhagen University Hospitals, Hvidovre Hospital, Dept. of Obstetrica and Gynecology, Kettegård Allé 30, DK-2650 Hvidovre, Denmark and Rigshospitalet, Fertility Clinic 4071, Blegdamsvej 9, Copenhagen Ø DK-2100, Denmark.
Recurrent Pregnancy Loss Unit, Capital Region, Copenhagen University Hospitals, Hvidovre Hospital, Dept. of Obstetrica and Gynecology, Kettegård Allé 30, DK-2650 Hvidovre, Denmark and Rigshospitalet, Fertility Clinic 4071, Blegdamsvej 9, Copenhagen Ø DK-2100, Denmark.
Reprod Biomed Online. 2021 Jun;42(6):1172-1180. doi: 10.1016/j.rbmo.2021.03.012. Epub 2021 Mar 23.
Are women and men suffering from recurrent pregnancy loss (RPL) more affected by psychological stress and depression than the general population?
Cross-sectional study investigating the prevalence of stress and depression in women and men with RPL seen in the Danish national RPL Unit. Data were collected between 2015-2018. All newly referred couples were asked to complete the Major Depression Index (MDI) and Cohen's Perceived Stress Scale (PSS). The scores of both sexes were compared with scores from relevant cohorts of men and women from the general population.
In total, 412 women with RPL (82% response rate) and 281 male partners (60% response rate) were included. Depression: 5/281 (1.8%) of men with RPL had moderate/severe depression vs. 5/253 (2.0%) of men in the comparison group (relative risk (RR) 0.90; 95% CI 0.26-3.07, p=0.99). Among women with RPL, 34/412 (8.3%) had a moderate/severe depression vs. 2.2% in the comparison group (RR 3.74; 95% CI 2.40-5.83, p<0.001). High stress levels were found in 30/281 men with RPL (10.7%) vs. 15.8% in the comparison group (co-habiting men) (RR 0.67; 95% CI 0.48-0.94, p=0.017). High stress level was found among 110/384 (28.6%) of RPL-women vs. 420/1813 (23.2%) of comparison women (RR 1.24; 95% CI 1.03-1.48, p=0.026). Both MDI and PSS scores, respectively, for a woman and a man in an RPL couple were significantly correlated.
Male partners in RPL couples did not have increased prevalence of stress and depression compared with other men but we confirmed our previous finding of significantly increased frequencies among women with RPL.
与普通人群相比，患有复发性妊娠丢失（RPL）的女性和男性是否受到更多的心理压力和抑郁困扰？
这是一项横断面研究，调查了丹麦国家 RPL 单位中 RPL 女性和男性的压力和抑郁患病率。数据收集于 2015-2018 年。所有新转诊的夫妇都被要求完成主要抑郁指数（MDI）和科恩的感知压力量表（PSS）。比较了两种性别的分数与普通人群中相应的男性和女性队列的分数。
共有 412 名 RPL 女性（82%的应答率）和 281 名男性伴侣（60%的应答率）被纳入研究。抑郁：281 名 RPL 男性中有 5 名（1.8%）患有中重度抑郁，而对照组中 253 名男性有 5 名（2.0%）（相对风险（RR）0.90；95%CI 0.26-3.07，p=0.99）。在 RPL 女性中，412 名中有 34 名（8.3%）患有中重度抑郁，而对照组中有 2.2%（RR 3.74；95%CI 2.40-5.83，p<0.001）。281 名 RPL 男性中有 30 名（10.7%）存在高压力水平，而对照组（同居男性）中有 15.8%（RR 0.67；95%CI 0.48-0.94，p=0.017）。384 名 RPL 女性中有 110 名（28.6%）存在高压力水平，而对照组 1813 名女性中有 420 名（23.2%）（RR 1.24；95%CI 1.03-1.48，p=0.026）。RPL 夫妇中女性和男性的 MDI 和 PSS 评分分别显著相关。
与其他男性相比，RPL 夫妇中的男性伴侣并没有更高的压力和抑郁发生率，但我们证实了我们之前的发现，即 RPL 女性的发生率显著增加。
