Andonopoulos A P, Constantopoulos S H, Galanopoulou V, Drosos A A, Acritidis N C, Moutsopoulos H M
Department of Medicine, School of Medicine, University of Ioannina, Greece.
Chest. 1988 Aug;94(2):312-5. doi: 10.1378/chest.94.2.312.
The pulmonary function of 70 nonsmoking patients with systemic lupus erythematosus (SLE) was evaluated, and the results were compared with those of 70 age- and sex-matched, nonsmoking healthy individuals. Isolated reduction of carbon monoxide diffusing lung capacity (DCO), usually subclinical, was the most commonly detected functional abnormality in the SLE population, whereas it was absent in the comparison group. Isolated small airways disease (SAD) was observed in a relatively high percentage of patients, but not significantly different from that in the healthy people. Restrictive and obstructive patterns were very unusual in the SLE people and absent in the members of the comparison group. Finally, normal lung function was seen in the majority of the latter, but only in one third of the lupus patients. Subclinical respiratory dysfunction, most commonly expressed as diminished DCO, is a common feature of SLE.
对70例不吸烟的系统性红斑狼疮（SLE）患者的肺功能进行了评估，并将结果与70例年龄和性别匹配的不吸烟健康个体的结果进行了比较。一氧化碳弥散肺容量（DCO）单独降低，通常为亚临床状态，是SLE人群中最常检测到的功能异常，而在对照组中则不存在。在相对较高比例的患者中观察到单独的小气道疾病（SAD），但与健康人群无显著差异。限制性和阻塞性模式在SLE患者中非常少见，在对照组中则不存在。最后，大多数对照组个体肺功能正常，而狼疮患者中只有三分之一肺功能正常。亚临床呼吸功能障碍，最常见的表现为DCO降低，是SLE的一个常见特征。
