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氧化石墨烯纳米结构作为天然治疗剂递送的纳米平台:在癌症治疗、细菌感染和骨再生医学中的应用。

Graphene Oxide Nanostructures as Nanoplatforms for Delivering Natural Therapeutic Agents: Applications in Cancer Treatment, Bacterial Infections, and Bone Regeneration Medicine.

作者信息

AbouAitah Khaled, Sabbagh Farzaneh, Kim Beom Soo

机构信息

Department of Chemical Engineering, Chungbuk National University, Cheongju 28644, Republic of Korea.

Medicinal and Aromatic Plants Research Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), 33 El-Behouth Street, Dokki, Giza 12622, Egypt.

出版信息

Nanomaterials (Basel). 2023 Sep 28;13(19):2666. doi: 10.3390/nano13192666.

Abstract

Graphene, fullerenes, diamond, carbon nanotubes, and carbon dots are just a few of the carbon-based nanomaterials that have gained enormous popularity in a variety of scientific disciplines and industrial uses. As a two-dimensional material in the creation of therapeutic delivery systems for many illnesses, nanosized graphene oxide (NGO) is now garnering a large amount of attention among these materials. In addition to other benefits, NGO functions as a drug nanocarrier with remarkable biocompatibility, high pharmaceutical loading capacity, controlled drug release capability, biological imaging efficiency, multifunctional nanoplatform properties, and the power to increase the therapeutic efficacy of loaded agents. Thus, NGO is a perfect nanoplatform for the development of drug delivery systems (DDSs) to both detect and treat a variety of ailments. This review article's main focus is on investigating surface functionality, drug-loading methods, and drug release patterns designed particularly for smart delivery systems. The paper also examines the relevance of using NGOs to build DDSs and considers prospective uses in the treatment of diseases including cancer, infection by bacteria, and bone regeneration medicine. These factors cover the use of naturally occurring medicinal substances produced from plant-based sources.

摘要

石墨烯、富勒烯、金刚石、碳纳米管和碳点只是在各种科学学科和工业应用中广受欢迎的几种碳基纳米材料。作为一种用于多种疾病治疗递送系统的二维材料,纳米氧化石墨烯(NGO)目前在这些材料中备受关注。除其他优点外,NGO还可作为一种药物纳米载体,具有出色的生物相容性、高药物负载能力、可控的药物释放能力、生物成像效率、多功能纳米平台特性,以及增强负载药物治疗效果的能力。因此,NGO是开发用于检测和治疗各种疾病的药物递送系统(DDS)的理想纳米平台。这篇综述文章的主要重点是研究专门为智能递送系统设计的表面功能、药物负载方法和药物释放模式。本文还探讨了使用NGO构建DDS的相关性,并考虑了其在治疗包括癌症、细菌感染和骨再生医学等疾病方面的潜在用途。这些因素包括使用从植物来源产生的天然药用物质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8de/10574074/0a3633898467/nanomaterials-13-02666-g001.jpg

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