Department of Chemistry and Nanotechnology, School of Engineering and Science, Tecnologico de Monterrey, Monterrey, Nuevo Leon, 64849, Mexico.
Department of Chemistry and Nanotechnology, School of Engineering and Science, Tecnologico de Monterrey, Monterrey, Nuevo Leon, 64849, Mexico.
Colloids Surf B Biointerfaces. 2021 Aug;204:111819. doi: 10.1016/j.colsurfb.2021.111819. Epub 2021 May 4.
Nanocomposite hydrogel particles grasp considerable attention in nanotechnology and nanomedicine as one of the potential drug delivery platforms. However, prevail a coveted drug delivery strategy with sustain and stimuli-drug release is still challenging. Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy. CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release. Under pH 7.4, CNPs exhibited the highest drug release at 55 °C in 15 days. The drug release results disclose that the structure of CNPs was disassembled at 55 °C to release the encapsulated drug molecules in a controlled fashion. The CNPs also displayed good cell viability against human fibroblast cells. Thus, all the results together unveil that CNPs would thrive as a promising pH and temperature-triggered drug delivery platform for the GI tract and colon targeted drug delivery.
纳米复合水凝胶颗粒作为潜在的药物输送平台之一，在纳米技术和纳米医学中引起了相当大的关注。然而，仍然具有挑战性的是，需要一种具有持续和刺激药物释放的理想药物输送策略。在此，使用离子凝胶化策略制备了聚（N-（4-氨基苯基）甲基丙烯酰胺）-碳纳米洋葱（PAPMA-CNOs= f-CNOs）/双氯芬酸复合物整合壳聚糖（CS）纳米复合水凝胶纳米颗粒（CNPs）。CNPs 具有多种有利的物理化学性质，包括球形形态和均匀的颗粒分布。在 37-55°C 的胃肠道（GI）环境不同 pH 值下对 CNPs 的体外药物释放进行了检测，并发现具有双重（pH 和热）响应控制药物释放。在 pH 7.4 下，CNPs 在 55°C 下在 15 天内表现出最高的药物释放。药物释放结果表明，在 55°C 下，CNPs 的结构被分解以控制方式释放包封的药物分子。CNPs 对人成纤维细胞也显示出良好的细胞活力。因此，所有结果共同揭示，CNPs 将作为胃肠道和结肠靶向药物输送的有前途的 pH 和温度触发药物输送平台而蓬勃发展。
