Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, United Kingdom.
Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, United Kingdom; Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
Nucl Med Biol. 2021 Jul-Aug;98-99:18-29. doi: 10.1016/j.nucmedbio.2021.03.010. Epub 2021 Apr 22.
In oncology, the holy grail of radiotherapy is specific radiation dose deposition in tumours with minimal healthy tissue toxicity. If used appropriately, injectable, systemic radionuclide therapies could meet these criteria, even for treatment of micrometastases and single circulating tumour cells. The clinical use of α and β particle-emitting molecular radionuclide therapies is rising, however clinical translation of Auger electron-emitting radionuclides is hampered by uncertainty around their exact subcellular localisation, which in turn affects the accuracy of dosimetry. This review aims to discuss and compare the advantages and disadvantages of various subcellular localisation methods available to localise radiopharmaceuticals and radionuclides for in vitro investigations.
在肿瘤学中，放射治疗的圣杯是在最小的健康组织毒性下将特定的辐射剂量沉积在肿瘤中。如果使用得当，可注射的、全身放射性核素疗法可以满足这些标准，甚至可以治疗微转移和单个循环肿瘤细胞。α 和 β 粒子发射的分子放射性核素疗法的临床应用正在增加，然而，由于电子俘获放射性核素的确切亚细胞定位的不确定性，其临床转化受到阻碍，这反过来又影响了剂量学的准确性。本综述旨在讨论和比较各种可用于体外研究的放射性药物和放射性核素的亚细胞定位方法的优缺点。
