Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM'S NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai, India.
Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM'S NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai, India.
Mater Sci Eng C Mater Biol Appl. 2021 Jun;125:112099. doi: 10.1016/j.msec.2021.112099. Epub 2021 Apr 16.
Smart polymeric materials and hydrogels derived from acrylate, epoxy resins, etc. mimic the healing ability of natural organisms and biological cells by showing shape memory and tissue regenerative properties wherein, the healing ability in some of the materials is triggered by external stimuli like temperature, pH and light. This article provides an overview of various conceptual strategies and chemical and mechanical interactions involved in the different types of biomimetic self-healing materials to regain the deformed structure by repairing the cracked shape which play important role in contributing to the structural properties and functional recovery. Also, different chemical bonding like π-π interaction, ligand-metal, hydrogen bonding, etc. takes place at the molecular level for replenishing the damaged structure with greater bond strength. The regeneration ability of artificial self-healing polymeric materials not only shows use in material sciences, engineering but also exhibits a wide range of applications in site-specific drug delivery, skin grafting, implantation, dentistry and bone and tissue regeneration to restore injured surfaces with better biocompatibility, healing efficiency and higher tensile strength to serve as a next-generation material for amplifying the use in biomedical field.
基于丙烯酸酯、环氧树脂等的智能聚合物材料和水凝胶通过表现出形状记忆和组织再生特性来模拟天然生物组织和细胞的愈合能力，其中一些材料的愈合能力是由温度、pH 值和光等外部刺激触发的。本文概述了不同类型仿生自修复材料中涉及的各种概念策略和化学机械相互作用，这些材料通过修复裂纹形状来恢复变形结构，这对结构性能和功能恢复起着重要作用。此外，分子水平上还会发生不同的化学键合，如π-π 相互作用、配体-金属键、氢键等，以增强键合强度来补充受损结构。人工自修复聚合物材料的再生能力不仅在材料科学和工程中有应用，而且在药物靶向释放、皮肤移植、植入物、牙科和骨组织再生等方面也有广泛的应用，以更好的生物相容性、愈合效率和更高的拉伸强度来恢复受损表面，可作为下一代材料在生物医学领域中得到更广泛的应用。
