Diabetes Clinic of Ravenna, Ravenna Dept of Internal Medicine, Romagna Local Health Authority, Italy.
Division of Endocrinology, Metabolism and Diabetes, Division of Cardiology, University of Colorado Anschutz Medical Campus, United States.
Diabetes Res Clin Pract. 2021 Jun;176:108857. doi: 10.1016/j.diabres.2021.108857. Epub 2021 May 7.
The history of insulin is rightly considered one of the most beautiful stories in medicine which goes even further than the extraordinary result of tens of millions of lives saved. Without a doubt, it constitutes a major achievement for medical science which, especially in the last 50 years, has led to an impressive acceleration in the succession of new treatment opportunities. We are going to describe the history of insulin therapy, the history we lived from two different angles as people living with type 1 diabetes, and obviously also as diabetologists, but as diabetologists with diabetes. Without a doubt, insulin and his story constitutes a major achievement for medical science which has led to an impressive acceleration in the succession of new treatment opportunities. Care opportunities that have not only allowed fundamental improvements in outcomes, but have also and above all impacted the quality of life of people with diabetes. Summarizing one hundred years of insulin is no simple endeavor. In our view, it would be easier, and probably more befitting, to focus on the last 50 years, namely the period we have lived closely and personally together with insulin. More to the point, these last 50 years have witnessed a dramatic acceleration of research and innovation. In our opinion, it is precisely the innovations in insulin therapy introduced from the last decades that fully justify the description of events in this incredible period as "the miracle of insulin". We'll describe how the most important innovations introduced in the last decades had impact on what we have nowadays, as patients and diabetologits: today, we can finally adapt insulin therapy to the patient's life or lifestyle, reversing what was the perception of patients until 20 years, when insulin was considered, by the most, as an obstacle, which seemed insurmountable to some, to a free and unconstrained life.
胰岛素的历史堪称医学史上最伟大的故事之一，其意义远超千万生命因此获救。毫无疑问，这是医学科学的一项重大成就，尤其是在过去的 50 年里，新的治疗机会层出不穷，令人瞩目。我们将描述胰岛素治疗的历史，我们作为 1 型糖尿病患者从两个不同的角度经历的历史，当然，我们也是作为糖尿病专家，但作为有糖尿病的糖尿病专家。毫无疑问，胰岛素及其故事是医学科学的一项重大成就，它使新的治疗机会不断涌现，令人印象深刻。这些治疗机会不仅使结局得到了根本改善，而且还极大地提高了糖尿病患者的生活质量。总结 100 年的胰岛素历史并非易事。在我们看来，关注过去的 50 年，也就是我们与胰岛素密切而个人地共同生活的时期，会更容易，也更合适。更确切地说，过去的 50 年见证了研究和创新的急剧加速。在我们看来，正是过去几十年引入的胰岛素治疗创新，完全证明了在这个令人难以置信的时期，将事件描述为“胰岛素的奇迹”是合理的。我们将描述过去几十年引入的最重要的创新如何影响我们今天的患者和糖尿病专家：今天，我们终于可以根据患者的生活或生活方式来调整胰岛素治疗，扭转 20 年前患者的认知，当时胰岛素被大多数人认为是一种障碍，对一些人来说似乎是不可逾越的，对一些人来说，它阻碍了他们过上自由和无拘无束的生活。
