Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, 54124, Greece.
Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, 54124, Greece.
Adv Drug Deliv Rev. 2021 Jul;174:387-405. doi: 10.1016/j.addr.2021.04.024. Epub 2021 May 7.
Molecular self-assembly has forged a new era in the development of advanced biomaterials for local drug delivery and tissue engineering applications. Given their innate biocompatibility and biodegradability, self-assembling peptides (SAPs) have come in the spotlight of such applications. Short and water-soluble SAP biomaterials associated with enhanced pharmacokinetic (PK) and pharmacodynamic (PD) responses after the topical administration of the therapeutic systems, or improved regenerative potential in tissue engineering applications will be the focus of the current review. SAPs are capable of generating supramolecular structures using a boundless array of building blocks, while peptide engineering is an approach commonly pursued to encompass the desired traits to the end composite biomaterials. These two elements combined, expand the spectrum of SAPs multi-functionality, constituting them potent biomaterials for use in various biomedical applications.
分子自组装为局部药物输送和组织工程应用中先进生物材料的发展开辟了一个新时代。由于其固有生物相容性和生物降解性，自组装肽 (SAP) 已成为此类应用的焦点。在局部给予治疗系统后，具有增强的药代动力学 (PK) 和药效学 (PD) 反应的短而水溶性 SAP 生物材料，或在组织工程应用中提高再生潜力，将是当前综述的重点。SAP 能够使用无限数量的构建块生成超分子结构，而肽工程是一种常用的方法，旨在将所需特性纳入最终复合生物材料中。这两个元素的结合，扩展了 SAP 的多功能性范围，使它们成为各种生物医学应用中的有力生物材料。
