Galun E, Burstein R, Tur-Kaspa I, Assia E, Epstein Y
Heller Institute of Medical Research, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Eur J Appl Physiol Occup Physiol. 1988;57(5):597-600. doi: 10.1007/BF00418468.
Physical performance deteriorates during strenuous exercise as manifested by a decrease in maximal aerobic power and increased activity of serum muscle enzymes. The relationship between these parameters was investigated in 41 trained subjects during 24 h marches and the following recovery period. Peak O2 uptake and serum activity of creatine phosphokinase (CPK) and glutamic oxalacetic transaminase (GOT) were measured. During the marches there was a simultaneous, significant elevation in serum CPK and GOT activity and a significant reduction in peak O2 uptake. During the early recovery period (24 h) no significant changes occurred in muscle enzyme activity and peak O2 uptake; thereafter (up to 72 h after the end of the march), a gradual decline in enzyme activity levels with a concomitant increase in peak O2 uptake was observed, reaching pre-march values. A "mirror image" relationship between muscle enzyme activity and peak O2 uptake was found during three clearly distinguished phases: a) 24 h march, b) early recovery stage and c) late recovery stage. These findings suggest that muscle enzyme leakage from muscle cells is closely related to the decline in muscular function and aerobic power. Thus, muscle enzyme activity might be a practical measure of physical performance capacity during the early and late stages of recovery from prolonged endurance exercise.
在剧烈运动期间，身体机能会下降，表现为最大有氧能力降低以及血清肌肉酶活性增加。在41名受过训练的受试者进行24小时行军及随后的恢复期期间，对这些参数之间的关系进行了研究。测量了峰值摄氧量以及肌酸磷酸激酶（CPK）和谷草转氨酶（GOT）的血清活性。在行军期间，血清CPK和GOT活性同时显著升高，而峰值摄氧量则显著降低。在恢复早期（24小时），肌肉酶活性和峰值摄氧量没有显著变化；此后（行军结束后长达72小时），观察到酶活性水平逐渐下降，同时峰值摄氧量增加，直至达到行军前的值。在三个明显不同的阶段中发现了肌肉酶活性与峰值摄氧量之间的“镜像”关系：a）24小时行军，b）恢复早期阶段和c）恢复后期阶段。这些发现表明，肌肉细胞中肌肉酶的泄漏与肌肉功能和有氧能力的下降密切相关。因此，肌肉酶活性可能是长时间耐力运动恢复早期和后期身体机能能力的一项实用指标。
