Janssen G M, Kuipers H, Willems G M, Does R J, Janssen M P, Geurten P
Department of Human Biology/Institute Sportsmedicine Limburg, Maastricht, The Netherlands.
Int J Sports Med. 1989 Oct;10 Suppl 3:S160-8. doi: 10.1055/s-2007-1024966.
One hundred fourteen sedentary volunteers (34 +/- 8 years) took part in an endurance training study to be completed after 18-20 months with a marathon. Ultimately, 60 males and 18 females achieved that goal. The training program, carefully supervised, was divided into three periods with a maximum of 45-, 70-, and 110-km week training volume and concluded with a performance race of 15, 25, and 42.2 km, respectively. Three days before and 3 and 5 days after each race, 35 subjects were selected to perform a progressive treadmill test and the remaining subjects participated in field tests of 400 and 1000 m. A significant decrease in half-life time of CK enzyme plasma activity after running long distances in the course of the study from 20 h to 13 h was observed. Based on plasma enzyme activity and supposing that the total enzyme content left the muscle fiber, the estimated amount of muscle damage was found to be small. A gender difference in plasma enzyme activity increase (females demonstrated a lower increase) occurred only after the marathon.
114名久坐不动的志愿者（年龄34±8岁）参与了一项耐力训练研究，该研究将在18至20个月后以马拉松比赛结束。最终，60名男性和18名女性达成了该目标。训练计划受到严格监督，分为三个阶段，每周最大训练量分别为45公里、70公里和110公里，最后分别进行15公里、25公里和42.2公里的达标赛。每次比赛前3天以及比赛后3天和5天，挑选35名受试者进行递增式跑步机测试，其余受试者参加400米和1000米的实地测试。在研究过程中，观察到长跑后CK酶血浆活性的半衰期从20小时显著降至13小时。根据血浆酶活性，并假设总酶含量离开了肌纤维，发现肌肉损伤的估计量很小。血浆酶活性增加方面的性别差异（女性增加幅度较低）仅在马拉松比赛后出现。
