University of Coimbra - Research Unit for Sport and Physical Activity (CIDAF, UID/PTD/04213/2019), Faculty of Sport Sciences and Physical Education, 3040-248 Coimbra, Portugal;
Higher Institute of Educational Sciences of the Douro, 4560-708 Penafiel, Portugal.
Exerc Immunol Rev. 2021;27:24-41.
Numerous epidemiological studies have shown the existence of a relationship between exercise and reduced risk of different types of cancer. In vitro studies have identified a direct effect of exercise-conditioned human serum on cancer cell lines of the lung, breast, prostate, and colon. The aim of this systematic review with meta-analysis (SRM) was to estimate the magnitude of the effect that exercise-conditioned human serum produced on the viability of cancer cell cultures. The design followed the PRISMA guidelines and the TREND statement to assess the quality of information (QoI) in each study. Nine in vitro studies were included in the SRM, involving a total of nine cancer cell lines and serum from 244 individuals from different countries, including namely healthy sedentary individuals, at risk of prostate cancer individuals and cancer patients, with ages ranging from 18 to 73 years. The impact of exerciseconditioned human serum on the viability of cancer cell cultures was analysed by a variety of assays, using pre-exercise human serum for comparison purposes. Globally, cultures of cancer cell lines exposed to human serum conditioned by exercise of various intensities exhibited a reduced viability, when compared with control cultures, with an overall effect size of -1.126 (95% CI; -1.300 to -0.952; p < 0.001). When the analysis only included human serum conditioned by high intensity exercise, the effect became more pronounced (ES -1.350; -1.522 to -1.179 (95% CI); p < 0.001). These results are in line with the hypothesis that changes in human serum induced by exercise might play a role in the beneficial effects of physical activity in cancer prevention and management and that these effects depend on exercise intensity.
大量的流行病学研究表明，运动与降低多种癌症的风险之间存在关联。体外研究已经发现，运动调节后的人体血清对肺癌、乳腺癌、前列腺癌和结肠癌的癌细胞系有直接影响。本系统评价和荟萃分析（SRM）旨在评估运动调节后的人体血清对癌细胞培养物活力的影响程度。该设计遵循 PRISMA 指南和 TREND 声明，以评估每项研究的信息质量（QoI）。SRM 纳入了 9 项体外研究，共涉及来自不同国家的 244 个人的 9 种癌细胞系和血清，包括健康的久坐个体、有前列腺癌风险的个体和癌症患者，年龄在 18 岁至 73 岁之间。通过使用运动前的人体血清进行比较，使用各种测定法分析运动调节后的人体血清对癌细胞培养物活力的影响。总体而言，与对照培养物相比，暴露于不同强度运动调节后的人体血清的癌细胞系培养物的活力降低，总体效应大小为-1.126（95%CI：-1.300 至-0.952；p<0.001）。当仅分析高强度运动调节后的人体血清时，效果更为明显（ES-1.350；-1.522 至-1.179（95%CI）；p<0.001）。这些结果与以下假设一致，即运动引起的人体血清变化可能在身体活动对癌症预防和管理的有益作用中发挥作用，并且这些作用取决于运动强度。
