Department of Biomedicine and Prevention, "Tor Vergata" University of Rome, 00133, Rome, Italy.
IRCCS Neuromed, Pozzilli, IS, Italy.
Hum Genomics. 2021 May 10;15(1):27. doi: 10.1186/s40246-021-00326-3.
COVID-19 has engulfed the world and it will accompany us all for some time to come. Here, we review the current state at the milestone of 1 year into the pandemic, as declared by the WHO (World Health Organization). We review several aspects of the on-going pandemic, focusing first on two major topics: viral variants and the human genetic susceptibility to disease severity. We then consider recent and exciting new developments in therapeutics, such as monoclonal antibodies, and in prevention strategies, such as vaccines. We also briefly discuss how advances in basic science and in biotechnology, under the threat of a worldwide emergency, have accelerated to an unprecedented degree of the transition from the laboratory to clinical applications. While every day we acquire more and more tools to deal with the on-going pandemic, we are aware that the path will be arduous and it will require all of us being community-minded. In this respect, we lament past delays in timely full investigations, and we call for bypassing local politics in the interest of humankind on all continents.
新冠疫情已经席卷全球，并将在未来一段时间内伴随我们所有人。在这里，我们回顾了世界卫生组织（WHO）宣布的疫情爆发一年之际的现状。我们回顾了疫情的几个方面，首先关注两个主要话题：病毒变异和人类对疾病严重程度的遗传易感性。然后，我们考虑了治疗方法的最新和令人兴奋的新进展，例如单克隆抗体，以及预防策略，例如疫苗。我们还简要讨论了在全球紧急情况下，基础科学和生物技术的进步如何以前所未有的速度从实验室加速过渡到临床应用。虽然我们每天都在获得更多的工具来应对持续的大流行，但我们意识到这将是一条艰难的道路，需要我们所有人都有社区意识。在这方面，我们对过去在及时进行全面调查方面的延误感到遗憾，并呼吁为了全人类的利益，绕过地方政治。
