Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA; Department of Biomedical Sciences, University at Albany, SUNY, Albany, NY 12222, USA.
Cell. 2021 May 13;184(10):2595-2604.e13. doi: 10.1016/j.cell.2021.03.061. Epub 2021 Apr 3.
The emergence and spread of SARS-CoV-2 lineage B.1.1.7, first detected in the United Kingdom, has become a global public health concern because of its increased transmissibility. Over 2,500 COVID-19 cases associated with this variant have been detected in the United States (US) since December 2020, but the extent of establishment is relatively unknown. Using travel, genomic, and diagnostic data, we highlight that the primary ports of entry for B.1.1.7 in the US were in New York, California, and Florida. Furthermore, we found evidence for many independent B.1.1.7 establishments starting in early December 2020, followed by interstate spread by the end of the month. Finally, we project that B.1.1.7 will be the dominant lineage in many states by mid- to late March. Thus, genomic surveillance for B.1.1.7 and other variants urgently needs to be enhanced to better inform the public health response.
SARS-CoV-2 谱系 B.1.1.7 的出现和传播引起了全球公共卫生关注，因为它具有更高的传染性。自 2020 年 12 月以来，美国已检测到与该变体相关的 2500 多例 COVID-19 病例，但该变体的建立程度尚不清楚。利用旅行、基因组和诊断数据，我们强调 B.1.1.7 在美国的主要入境口岸是纽约、加利福尼亚和佛罗里达。此外，我们发现有证据表明，从 2020 年 12 月初开始，就有许多独立的 B.1.1.7 建立，到月底就已经在州际传播。最后，我们预计到 3 月中旬至下旬，B.1.1.7 将成为许多州的主要谱系。因此，迫切需要加强对 B.1.1.7 和其他变体的基因组监测，以便更好地为公共卫生应对措施提供信息。
