纤维肌痛患者的天气敏感性与生活质量的关系。
Weather sensitivity associated with quality of life in patients with fibromyalgia.
作者信息
Hayashi Kazuhiro, Miki Kenji, Hayashi Noriyuki, Hashimoto Ryota, Yukioka Masao
机构信息
Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan.
Center for pain management, Hayaishi Hospital, Osaka, Japan.
出版信息
BMC Rheumatol. 2021 May 10;5(1):14. doi: 10.1186/s41927-021-00185-4.
BACKGROUND
Fibromyalgia is characterized by chronic widespread pain, and more than half of patients with fibromyalgia report that weather-related variables aggravate their symptoms. However, the differences in actual symptoms have not been measured between those with and without weather sensitivity. The present study aimed to investigate whether weather sensitivity associated with the minimal clinically important difference values of quality of life in patients with fibromyalgia, between those with and without weather sensitivity.
METHODS
Sixty-four consecutive outpatients with fibromyalgia on their first visit to our tertiary center were included. Weather sensitivity was measured using self-perceived symptoms. Pain intensity was measured using the 0-10 Numerical Rating Scale (NRS). Quality of life was measured using the Euro Quality of life-5 Dimensions-3 level (EQ-5D-3L) scale. The variables were subjected to univariable and multivariable analysis using the EQ-5D-3L scale.
RESULTS
The mean age of the patients was 50 years. Forty-eight patients (75%) were women. The mean EQ-5D-3L score was 0.55. Thirty-seven patients (58%) reported weather sensitivity. In univariable analysis, the welfare recipient, weather sensitivity, and NRS values were associated with EQ-5D-3L scale scores. In multivariable analysis, NRS value and weather sensitivity were independently associated with EQ-5D-3L scale scores. The NRS and EQ-5D-3L scale scores were significantly worse in those with weather sensitivity than those without weather sensitivity. The difference in NRS values was less than 1.5 points between groups. The differences in EQ-5D-3L scale scores were 0.16 points between groups.
CONCLUSIONS
Weather sensitivity was significantly associated with quality of life in patients with fibromyalgia. There was an association with weather sensitivity and the minimal clinically important difference values of quality of life in patients with fibromyalgia. The presence of weather sensitivity could have a key role in the quality of life in patients with fibromyalgia.
背景
纤维肌痛的特征是慢性广泛性疼痛，超过半数的纤维肌痛患者报告与天气相关的变量会加重他们的症状。然而，尚未对有天气敏感性和无天气敏感性的患者之间的实际症状差异进行测量。本研究旨在调查在有天气敏感性和无天气敏感性的纤维肌痛患者中，天气敏感性是否与生活质量的最小临床重要差异值相关。
方法
纳入64例首次就诊于我们三级中心的连续性纤维肌痛门诊患者。使用自我感知症状来测量天气敏感性。使用0至10数字评定量表（NRS）测量疼痛强度。使用欧洲五维健康量表3级（EQ-5D-3L）测量生活质量。使用EQ-5D-3L量表对变量进行单变量和多变量分析。
结果
患者的平均年龄为50岁。48例患者（75%）为女性。EQ-5D-3L量表的平均得分为0.55。37例患者（58%）报告有天气敏感性。在单变量分析中，福利受助者、天气敏感性和NRS值与EQ-5D-3L量表得分相关。在多变量分析中，NRS值和天气敏感性与EQ-5D-3L量表得分独立相关。有天气敏感性的患者的NRS和EQ-5D-3L量表得分显著低于无天气敏感性的患者。两组之间NRS值的差异小于1.5分。两组之间EQ-5D-3L量表得分的差异为0.16分。
结论
天气敏感性与纤维肌痛患者的生活质量显著相关。纤维肌痛患者的天气敏感性与生活质量的最小临床重要差异值之间存在关联。天气敏感性的存在可能在纤维肌痛患者的生活质量中起关键作用。
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