Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
Optom Vis Sci. 2021 May 1;98(5):450-455. doi: 10.1097/OPX.0000000000001684.
Ocular surface squamous neoplasias are superficial tumors of the cornea and conjunctiva that can be sight threatening if neglected. Therefore, accurate noninvasive diagnostic modalities are needed.
The purpose of this case series was to describe the hallmark features of ocular surface squamous neoplasia on high-resolution optical coherence tomography (HR-OCT) imaging and its use in the evaluation and management of superficial ocular tumors.
Five eyes of four patients with ocular surface squamous neoplasia are described. Whereas two eyes displayed the classic clinical features of ocular surface squamous neoplasia, three of the five eyes had more subtle atypical features. However, all shared features on HR-OCT of epithelial thickening and hyperreflectivity with abrupt transitions between normal and abnormal tissue, classic features of ocular surface squamous neoplasia. All lesions ultimately underwent incisional or excisional biopsy and were confirmed to be ocular surface squamous neoplasia on histopathology.
Ocular surface squamous neoplasia may present as a classic tumor but can also have subtle features or masquerade. Accurate methods to diagnose and manage patients with ocular surface squamous neoplasia are necessary. With recent advancements in technology, HR-OCT has been demonstrated to accurately identify ocular surface squamous neoplasia with the repeatable optical findings of (1) epithelial thickening, (2) epithelial hyperreflectivity, and (3) abrupt transition zone between normal and abnormal tissue. This case series demonstrates how HR-OCT can help provide an optical biopsy to guide appropriate diagnosis and management of this neoplastic lesion.
眼表鳞状细胞肿瘤是角膜和结膜的浅表性肿瘤，如果忽视，可能会对视力造成威胁。因此，需要准确的非侵入性诊断方法。
本病例系列旨在描述高分辨率光学相干断层扫描（HR-OCT）成像中眼表鳞状细胞肿瘤的特征标志，并描述其在评估和管理浅表性眼肿瘤中的应用。
描述了 4 例 5 只眼的眼表鳞状细胞肿瘤患者。其中 2 只眼表现出眼表鳞状细胞肿瘤的典型临床特征，而 5 只眼中的 3 只眼具有更微妙的非典型特征。然而，所有病变在 HR-OCT 上均具有上皮增厚和高反射性，以及正常组织和异常组织之间的突然过渡，这是眼表鳞状细胞肿瘤的典型特征。所有病变最终均进行了切开或切除活检，并通过组织病理学证实为眼表鳞状细胞肿瘤。
眼表鳞状细胞肿瘤可能表现为典型肿瘤，但也可能具有微妙的特征或伪装。需要准确的方法来诊断和管理眼表鳞状细胞肿瘤患者。随着技术的最新进展，HR-OCT 已被证明可以准确识别眼表鳞状细胞肿瘤，具有可重复的光学特征，包括（1）上皮增厚、（2）上皮高反射性和（3）正常组织与异常组织之间的突然过渡区。本病例系列表明，HR-OCT 如何有助于提供光学活检，以指导对这种肿瘤病变的适当诊断和管理。
