Kozma Kincső, Kajtár Béla, Orosz Zsuzsanna Zita, Nagy Bence, Csutak Adrienne, Szalai Eszter
Department of Ophthalmology, University of Pécs Medical School, Rakoczi u. 2, Pecs, 7623, Hungary.
Department of Pathology, University of Pécs Medical School, Rakoczi u. 2, Pecs, 7623, Hungary.
BMC Ophthalmol. 2025 May 22;25(1):307. doi: 10.1186/s12886-025-04137-1.
The purpose of this retrospective study was to analyze the features of different ocular surface lesions using high resolution swept-source optical coherence tomography (OCT) and to correlate those characteristics with histopathologic alterations.
Thirty-eight eyes of 37 patients (19 males and 18 females) were included in this study with a mean age of 60.36 ± 17.29 years years. Anterior segment imaging was performed with a swept-light source OCT system (ANTERION, Heidelberg Engineering, Germany) using the Imaging App. Clinical diagnosis based on the slit-lamp findings was compared with the OCT features of the lesion and the histopathology result.
Based on the OCT features, 11 lesions were in the epithelium, of which 5 had only epithelial component. Six growths had both epithelial and subepithelial components and 27 lesions were confined to the substantia propria. The OCT finding and histopathology result correlated in 57% (6/11) for epithelial involvement and in 84% (28/33) for subepithelial involvement. In 25 cases (65%), the clinical and histopathology diagnosis agreed. In 13 cases (35%), the clinical suspicion was different from the final histopathology diagnosis. Out of those 13 cases, high-resolution OCT findings were suggestive of the histopathology results in 8 cases.
High-resolution swept-source OCT provided valuable information of the structure, topographic location and extent of an ocular surface lesion and was helpful in assisting the diagnosis.
本回顾性研究旨在利用高分辨率扫频源光学相干断层扫描（OCT）分析不同眼表病变的特征，并将这些特征与组织病理学改变相关联。
本研究纳入了37例患者的38只眼（男性19例，女性18例），平均年龄为60.36±17.29岁。使用扫频光源OCT系统（德国海德堡工程公司的ANTERION）及成像应用程序进行眼前节成像。将基于裂隙灯检查结果的临床诊断与病变的OCT特征及组织病理学结果进行比较。
根据OCT特征，11个病变位于上皮层，其中5个仅具有上皮成分。6个病变同时具有上皮和上皮下成分，27个病变局限于固有层。上皮受累的OCT表现与组织病理学结果的相关性为57%（6/11），上皮下受累的相关性为84%（28/33）。25例（65%）临床诊断与组织病理学诊断一致。13例（35%）临床怀疑与最终组织病理学诊断不同。在这13例中，高分辨率OCT表现有8例提示了组织病理学结果。
高分辨率扫频源OCT提供了眼表病变的结构、地形位置和范围的有价值信息，有助于辅助诊断。
