Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Central Jakarta, Jakarta, Republic of Indonesia.
Pathologica. 2023 Jun;115(3):155-163. doi: 10.32074/1591-951X-842.
This study was done to quantify the prevalence of high cytokeratin (CK) 19 expression in Indonesian oral squamous cell carcinoma (OSCC) patients and explore the prognostic role of CK19 in OSCC.
Clinical data and samples from 61 patients diagnosed with OSCC at a tertiary national referral hospital in Jakarta, Indonesia were analyzed in this retrospective cohort study. Immunohistochemical staining of CK19 was performed on all patients and its expression was scored using the H system. All patients were followed up for a minimum of 36 months after diagnosis. Comparative and survival analyses were performed.
Twenty six point two percent of Indonesian OSCC patients had high CK19 expression. There were no differences in clinicopathological characteristics between patients with low and high CK19 expression. The 3-year overall survival (OS) of our cohort was 11.5%. Patients with high CK19 expression had lower 3-year OS compared to patients with low CK19 expression, even if the difference in OS was not statistically significant. Keratinization was an independent prognostic factor for survival in multivariate regression analysis.
Data obtained here indicate a possible prognostic role of CK19 in OSCC. This prognostic role should be confirmed in larger series.
本研究旨在定量评估印度尼西亚口腔鳞状细胞癌（OSCC）患者中细胞角蛋白 19（CK19）高表达的流行率，并探讨 CK19 在 OSCC 中的预后作用。
本回顾性队列研究分析了在印度尼西亚雅加达一家三级国家转诊医院诊断为 OSCC 的 61 例患者的临床数据和样本。对所有患者进行 CK19 免疫组织化学染色，并使用 H 系统对其表达进行评分。所有患者在诊断后至少随访 36 个月。进行了比较和生存分析。
26.2%的印度尼西亚 OSCC 患者存在 CK19 高表达。低 CK19 表达和高 CK19 表达患者的临床病理特征无差异。本队列的 3 年总生存率（OS）为 11.5%。与 CK19 低表达患者相比，CK19 高表达患者的 3 年 OS 较低，尽管 OS 差异无统计学意义。角化是多变量回归分析中生存的独立预后因素。
此处获得的数据表明 CK19 在 OSCC 中可能具有预后作用。这一预后作用应在更大的系列中得到证实。
