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miRNA 单核苷酸多态性与宫颈癌的关联及作用。

The associations and roles of microRNA single-nucleotide polymorphisms in cervical cancer.

机构信息

Department of Immunogenetics, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan, China.

出版信息

Int J Med Sci. 2021 Apr 7;18(11):2347-2354. doi: 10.7150/ijms.57990. eCollection 2021.

DOI:10.7150/ijms.57990
PMID:33967611
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8100648/
Abstract

Cervical cancer is one of the fourth most common gynecological malignancies and has been identified as the fourth leading cause of cancer death in women worldwide. MicroRNAs (miRNAs) are single-stranded sequences of noncoding RNAs that are approximately 22-24 nucleotides in length. They modulate posttranscriptional mRNA expression and play critical roles in cervical cancer. Single nucleotide polymorphisms (SNPs) in miRNA genes may alter miRNA expression and maturation and have been associated with various cancers. This review mainly focuses on the roles of SNPs in miRNA genes in the development of cervical cancer and summarizes the research progress of miRNA SNPs in cervical cancer and their molecular regulation mechanisms.

摘要

宫颈癌是第四大常见妇科恶性肿瘤之一，已被确定为全球女性癌症死亡的第四大主要原因。微小 RNA（miRNA）是约 22-24 个核苷酸长的单链非编码 RNA 序列。它们调节转录后 mRNA 的表达，在宫颈癌中发挥关键作用。miRNA 基因中的单核苷酸多态性（SNP）可能改变 miRNA 的表达和成熟，并与各种癌症有关。本综述主要关注 miRNA 基因 SNP 在宫颈癌发展中的作用，并总结了 miRNA SNP 在宫颈癌中的研究进展及其分子调控机制。

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