Zhang Kaihua, Li Yiran, He Jiarui, Xu Jiasheng, Wan Yanhua, Wan Shasha, Wang Riwei, Zeng Qingfu
Department of Vascular Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Department of General Surgery, The Jiujiang Affiliated Hospital of Nanchang University and Jiujiang First People's Hospital, Nanchang, China.
Front Pharmacol. 2021 Apr 23;12:627098. doi: 10.3389/fphar.2021.627098. eCollection 2021.
To investigate the clinical efficacy of epidermal growth factor combined with nano silver dressing in the treatment of diabetic foot wounds. A total of 160 patients with diabetic foot ulcers admitted to the Second Affiliated Hospital of Nanchang University from 2015-06 to 2018-06 were selected to participate in the experiment. A randomized table method was used to randomly divide 160 patients into 4 groups: 40 in the epidermal growth factor group, 40 in the nano-silver dressing group, 40 in the combined group, and 40 in the saline control group (normal saline). The healing stage of the wound surface and the growth degree of granulation tissue were graded. Each group was given a dressing change every other day, and the time required for wound repairing to each healing stage was observed. After 2 and 4 weeks of treatment, the wound exudate was collected for bacterial culture. There was no significant difference in the time between the four groups of patients reaching the effective phase of treatment (level 1). Compared with the control group, the epidermal growth factor group and the combined group achieved a shorter time for wound repairing to healing stages 2 and 3, and the difference was significant ( < 0.05). The combined group had a shorter wound repairing time than the epidermal growth factor group ( < 0.05). Compared with the control group, the positive rate of bacteria in the combined group and the silver nanoparticles group was significantly lower after 2 and 4 weeks of treatment. There is no significant difference in wound healing between the four groups during the clinically effective period. After this period, the combined use of recombinant epidermis Growth factors and nano-silver dressings have a significant effect on promoting wound healing and can effectively prevent infection.
探讨表皮生长因子联合纳米银敷料治疗糖尿病足创面的临床疗效。选取2015年6月至2018年6月南昌大学第二附属医院收治的160例糖尿病足溃疡患者参与实验。采用随机数字表法将160例患者随机分为4组：表皮生长因子组40例、纳米银敷料组40例、联合组40例、生理盐水对照组（生理盐水）40例。对创面愈合阶段及肉芽组织生长程度进行分级。每组隔日换药1次，观察创面修复至各愈合阶段所需时间。治疗2周和4周后，收集创面渗出液进行细菌培养。四组患者达到治疗有效阶段（1级）的时间差异无统计学意义。与对照组比较，表皮生长因子组和联合组创面修复至2级和3级愈合阶段的时间较短，差异有统计学意义（<0.05）。联合组创面修复时间短于表皮生长因子组（<0.05）。与对照组比较，治疗2周和4周后联合组和纳米银颗粒组细菌阳性率显著降低。在临床有效期间四组创面愈合差异无统计学意义。此阶段后，重组表皮生长因子与纳米银敷料联合应用对促进创面愈合有显著作用，且能有效预防感染。
