The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
The Sun Yet-sen University, Guangzhou, China.
Burns. 2021 May;47(3):643-653. doi: 10.1016/j.burns.2019.12.015. Epub 2020 Jan 22.
The purpose of this meta-analysis was to assess the efficacy and safety of nano-silver dressing combined with recombinant human epidermal growth factor for deep second-degree burns.
PubMed, Web of Science, EMBASE, Cochrane Library and other databases were searched to identify relevant randomised controlled trials.
Twelve studies that assessed nano-silver dressing combined with recombinant human epidermal growth factor were identified. Nano-silver dressing combined with recombinant human epidermal growth factor for deep second-degree burns could significantly reduce the duration of wound healing (mean difference -5.68, 95% CI -7.38 - -3.99, P<0.00001), the wound healing rate (risk ratio [RR] 0.34, 95% CI 0.23-0.48, P<0.00001), the rate of scar hyperplasia (RR 0.67, 95% CI 0.54-0.84, P=0.0004), the wound bacterial positive rate (RR 0.50, 95% CI 0.28-0.89, P=0.02), and the adverse reactions rate (RR 0.31, 95% CI 0.16-0.58, P=0.0003).
This comprehensive meta-analysis of the available evidence suggest that the use of nano-silver dressing combined with recombinant human epidermal growth factor results in shorter duration of wound healing, reduced wound bacterial positive rates and adverse reactions rate, and improved wound healing rates.
本荟萃分析旨在评估纳米银敷料联合重组人表皮生长因子治疗深二度烧伤的疗效和安全性。
检索 PubMed、Web of Science、EMBASE、Cochrane 图书馆等数据库，以确定相关的随机对照试验。
共确定了 12 项评估纳米银敷料联合重组人表皮生长因子治疗深二度烧伤的研究。纳米银敷料联合重组人表皮生长因子治疗深二度烧伤可显著缩短创面愈合时间（均数差-5.68，95%置信区间-7.38 至-3.99，P<0.00001）、创面愈合率（风险比[RR]0.34，95%置信区间 0.23-0.48，P<0.00001）、瘢痕增生率（RR 0.67，95%置信区间 0.54-0.84，P=0.0004）、创面细菌阳性率（RR 0.50，95%置信区间 0.28-0.89，P=0.02）和不良反应发生率（RR 0.31，95%置信区间 0.16-0.58，P=0.0003）。
本荟萃分析综合评估了现有证据，表明纳米银敷料联合重组人表皮生长因子可缩短创面愈合时间，降低创面细菌阳性率和不良反应发生率，提高创面愈合率。
