使用穆勒光学相干断层扫描技术检测Sencar小鼠皮肤癌的初步研究。
PRELIMINARY STUDY ON SKIN CANCER DETECTION IN SENCAR MICE USING MUELLER OPTICAL COHERENCE TOMOGRAPHY.
作者信息
Todorović Miloš, Jiao Shuliang, Stoica George, Wang Lihong V
机构信息
Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843-3120, USA.
Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
出版信息
J Innov Opt Health Sci. 2009 Jul;2(3):289-294. doi: 10.1142/s1793545809000577.
Abstract
We report on the use of a fiber-based Mueller-matrix optical coherence tomography (OCT) system with continuous source-polarization modulation for imaging of early stages of skin cancer in SENCAR mice. A homemade hand-held probe with integrated optical scanning and beam delivering optics was coupled in the sample arm. The OCT images show the morphological changes in skin resulting from pre-cancerous papilloma formations that are consistent with histology, thus demonstrating the system's potential for early skin cancer detection.
摘要
我们报告了一种基于光纤的穆勒矩阵光学相干断层扫描（OCT）系统的应用，该系统采用连续光源偏振调制对SENCAR小鼠皮肤癌早期阶段进行成像。在样品臂中耦合了一个集成光学扫描和光束传输光学器件的自制手持式探头。OCT图像显示了由癌前乳头瘤形成导致的皮肤形态变化，这与组织学结果一致，从而证明了该系统在早期皮肤癌检测方面的潜力。
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