对掺入小鼠体内的238钚的遗传效应评估。
Evaluation of the genetic effects of 238Pu incorporated into mice.
作者信息
Pomerantseva M D, Ramaya L K, Shevchenko V A, Vilkina G A, Lyaginskaya A M
机构信息
N.I. Vavilov Institute of General Genetics, U.S.S.R. Academy of Sciences, Moscow.
出版信息
Mutat Res. 1989 Jun;226(2):93-8. doi: 10.1016/0165-7992(89)90049-3.
The genetic effects of 238Pu incorporated into male mice were estimated by several tests. The activity of the administered 238Pu nitrate varied from 7 to 1850 Bq/g of body weight. The average alpha-radiation dose absorbed in the testes ranged from 2 to 96 cGy, with a dose rate of 0.004-1 cGy/day. alpha-Radiation from 238Pu was shown to induce dominant lethal mutations (DLM) and reciprocal translocation (RT), chromosomal fragmentation and formation of abnormal sperm heads (ASH). The effect does not depend on the average alpha-radiation dose absorbed in the testis. The relative genetic efficiency of alpha-radiation, as compared with that of chronic alpha-radiation for the indices under study, was about 10-20.
通过多项测试评估了雄性小鼠体内掺入的238Pu的遗传效应。所施用的硝酸钚238的活度为每克体重7至1850贝可勒尔。睾丸吸收的平均α辐射剂量为2至96厘戈瑞，剂量率为0.004 - 1厘戈瑞/天。钚238发出的α辐射可诱发显性致死突变（DLM）和相互易位（RT）、染色体断裂以及异常精子头部（ASH）的形成。该效应不取决于睾丸吸收的平均α辐射剂量。与慢性α辐射相比，在所研究指标方面，α辐射的相对遗传效率约为10 - 20。
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