Mandal Dibyakanti, Desai Devashish, Sinha Sanjeev
Department of Internal Medicine, All India Institute of Medical Sciences, New Delhi, India.
Department of Biochemistry, Faculty of Life Sciences, PDM University, Sector-3A, Bahadurgarh, Haryana 124507 India.
Virusdisease. 2021 Mar;32(1):137-139. doi: 10.1007/s13337-020-00649-0. Epub 2021 Mar 19.
Epstein-Barr Virus (EBV) is associated with the Hodgkin's and Non-Hodgkin's lymphoma (HL and NHL respectively). HIV is a risk factor for EBV infections and previously published data indicate that HIV infected individuals have higher chances of getting EBV infections compared to HIV uninfected individuals. Very limited information is available from India about the the prevalence of EBV in HIV positivity, with or without malignancy. In a recent study (Sinha et al. Current HIV Res 16:1-6, 2018) from All India Institute of Medical Sciences (AIIMS), New Delhi, we have shown that 2% among the HIV-1 infected individuals have malignancies including HL and NHL. To determine the prevalence of EBV among these individuals, clinical specimen obtained from ART clinic of AIIMS were tested for the presence of EBV DNA in plasma samples by quantitative real-time PCR. We have observed high prevalence of EBV (30%) among the 92 specimen tested. Prevalence is higher in patients with malignancy (37%) compared to those without maliganancy (27%). No correlation was observed with the CD4 counts or HIV viral load with EBV positivity.
爱泼斯坦-巴尔病毒（EBV）与霍奇金淋巴瘤和非霍奇金淋巴瘤（分别为HL和NHL）相关。HIV是EBV感染的一个风险因素，先前发表的数据表明，与未感染HIV的个体相比，感染HIV的个体感染EBV的几率更高。在印度，关于HIV阳性个体（无论有无恶性肿瘤）中EBV流行情况的信息非常有限。在新德里全印度医学科学研究所（AIIMS）最近的一项研究（Sinha等人，《当代HIV研究》16:1 - 6，2018年）中，我们发现2%的HIV - 1感染个体患有包括HL和NHL在内的恶性肿瘤。为了确定这些个体中EBV的流行情况，通过定量实时PCR检测了从AIIMS抗逆转录病毒治疗诊所获取的临床标本血浆样本中EBV DNA 的存在情况。我们观察到在检测的92份标本中EBV的流行率很高（30%）。与无恶性肿瘤的患者（27%）相比，患有恶性肿瘤的患者中EBV流行率更高（37%）。未观察到EBV阳性与CD4细胞计数或HIV病毒载量之间存在相关性。
