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雾化氯胺酮用于小儿急诊科急性疼痛的管理:病例系列

Nebulized ketamine for managing acute pain in the pediatric emergency department: A case series.

作者信息

Rhodes Adam James, Fagan Michele Joy, Motov Sergey M, Zerzan Jessica

机构信息

Department of Emergency Medicine, Maimonides Medical Center, 4802 10th Avenue, Brooklyn, NY, USA.

出版信息

Turk J Emerg Med. 2021 Apr 9;21(2):75-78. doi: 10.4103/2452-2473.313334. eCollection 2021 Apr-Jun.

DOI:10.4103/2452-2473.313334
PMID:33969243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8091994/
Abstract

Administration of sub-dissociative doses of ketamine is used via intranasal (IN) and intravenous routes in the pediatric emergency department for managing acute pain. Due to difficulties in both obtaining intravenous access and compliance with IN medications in children, administration of ketamine via breath-actuated nebulizer can serve as a valuable modality for timely analgesia in children where dosing titration is patient controlled. We describe five pediatric patients who received ketamine via breath-actuated nebulizer at 0.75 mg/kg, 1 mg/kg, and 1.5 mg/kg, with all patients experiencing a decrease in pain score. This case series introduces ketamine inhalation as a modality for managing pain in children.

摘要

在儿科急诊科,通过鼻内(IN)和静脉途径给予亚解离剂量的氯胺酮用于管理急性疼痛。由于儿童获得静脉通路困难以及对鼻内用药的依从性问题,通过呼吸驱动雾化器给予氯胺酮可作为一种有价值的方式,用于在剂量滴定由患者控制的儿童中及时镇痛。我们描述了5例儿科患者,他们通过呼吸驱动雾化器接受了0.75mg/kg、1mg/kg和1.5mg/kg剂量的氯胺酮,所有患者的疼痛评分均有所下降。本病例系列介绍了氯胺酮吸入作为一种管理儿童疼痛的方式。

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本文引用的文献

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[Preemptive nebulized ketamine for pain control after tonsillectomy in children: randomized controlled trial].[儿童扁桃体切除术后预防性雾化吸入氯胺酮用于疼痛控制:随机对照试验]
Braz J Anesthesiol. 2019 Jul-Aug;69(4):350-357. doi: 10.1016/j.bjan.2019.03.007. Epub 2019 Jul 28.
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World J Emerg Med. 2018;9(4):249-255. doi: 10.5847/wjem.j.1920-8642.2018.04.002.
3
Analgesic Efficacy of Intranasal Ketamine Versus Intranasal Fentanyl for Moderate to Severe Pain in Children: A Prospective, Randomized, Double-Blind Study.鼻腔内给予氯胺酮与鼻腔内给予芬太尼治疗儿童中重度疼痛的镇痛效果:一项前瞻性、随机、双盲研究。
Pediatr Emerg Care. 2021 May 1;37(5):250-254. doi: 10.1097/PEC.0000000000001556.
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Nebulized Fentanyl in Acute Pain: A Systematic Review.雾化芬太尼用于急性疼痛:一项系统评价
Ann Pharmacother. 2016 Oct;50(10):882-91. doi: 10.1177/1060028016659077. Epub 2016 Jul 12.
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Ketamine use in current clinical practice.氯胺酮在当前临床实践中的应用。
Acta Pharmacol Sin. 2016 Jul;37(7):865-72. doi: 10.1038/aps.2016.5. Epub 2016 Mar 28.
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Anesth Essays Res. 2014 Sep-Dec;8(3):283-90. doi: 10.4103/0259-1162.143110.
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