State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China.
Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
Biochemistry. 2021 Nov 23;60(46):3410-3412. doi: 10.1021/acs.biochem.1c00254. Epub 2021 May 10.
To date more than 150 kinds of RNA chemical modifications have been identified in cellular RNAs, among which N6-methyladenosine (m6A) is the most prevalent mRNA modification in higher eukaryotes. m6A is widely conserved among eukaryotes and tends to occur in a RRACH consensus motif. This consensus motif is identified as early as the 1970s and positively influences the subsequent epigenetic studies. This viewpoint discusses the discovery of this m6A consensus motif and the latest studies around it.
迄今为止，已在细胞 RNA 中鉴定出超过 150 种 RNA 化学修饰，其中 N6-甲基腺苷（m6A）是高等真核生物中最普遍的 mRNA 修饰。m6A 在真核生物中广泛保守，倾向于出现在 RRACH 共识基序中。早在 20 世纪 70 年代，就已经确定了这个共识基序，并对随后的表观遗传研究产生了积极影响。本文讨论了这一 m6A 共识基序的发现及其最新研究进展。
