Kaufman F L, Mills D E, Hughson R L, Peake G T
Department of Kinesiology, University of Waterloo, Ont., Canada.
Horm Res. 1988;29(1):31-8. doi: 10.1159/000180962.
This study examined the involvement of the hormones aldosterone and prolactin in sweat gland function during heat acclimatization. Two groups of male subjects (n = 8) were tested - one receiving a placebo (control), the other receiving bromocriptine. Both groups performed cycle ergometer exercise at 50% of maximal oxygen uptake over 10 consecutive days in an environmental chamber maintained at 39 degrees C and 30% relative humidity. Duration of exercise was 90 min on days 2-4 and 6-9, and 45 min on test days 1, 5 and 10. Electrolyte concentrations were determined by total body washdown. Prolactin increased (p less than 0.001) during exercise on day 1 in the control group but not on days 5 and 10. In contrast, prolactin was suppressed by bromocriptine and did not rise in response to exercise or heat exposure. Plasma aldosterone increased during exercise in both groups, showing no differences between groups. The sodium concentration in sweat decreased significantly (p less than 0.05) in the control group from day 1 to 10 but was unchanged in the treatment group. These data suggest that acclimatization-related changes in sweat gland function may be attenuated by increases in central dopaminergic activity and implicate prolactin in control of sweat gland function.
本研究探讨了醛固酮和催乳素这两种激素在热适应过程中对汗腺功能的影响。对两组男性受试者（每组n = 8）进行了测试，一组接受安慰剂（对照组），另一组接受溴隐亭。两组受试者均在温度保持在39摄氏度、相对湿度为30%的环境舱内，以最大摄氧量的50%进行连续10天的蹬车测力计运动。第2 - 4天和第6 - 9天的运动时长为90分钟，测试日第1天、第5天和第10天的运动时长为45分钟。通过全身冲洗来测定电解质浓度。对照组在第1天运动期间催乳素水平升高（p < 0.001），但在第5天和第10天未升高。相比之下，溴隐亭抑制了催乳素水平，其在运动或热暴露后未升高。两组运动期间血浆醛固酮均升高，两组间无差异。对照组汗液中的钠浓度从第1天到第10天显著降低（p < 0.05），而治疗组则无变化。这些数据表明，中枢多巴胺能活性增加可能会减弱与适应相关的汗腺功能变化，且提示催乳素参与汗腺功能的调控。
