Miñarro J, Castaño D, Brain P F, Simón V M
Area de Psicobiología, Facultad de Psicología, Universitat de Valencia, Spain.
Physiol Behav. 1990 Feb;47(2):281-5. doi: 10.1016/0031-9384(90)90143-r.
The possibility that antipsychotic drugs antagonize the behavioural effects of stress on agonistic behaviour has been explored. Male mice of the OF.1 strain were subjected to the following treatments: 1) Immobilization stress (ten or twenty minutes in duration), 2) haloperidol (three doses) and 3) immobilization stress (ten minutes) plus haloperidol. Individually housed experimental animals confronted standard opponents (anosmic animals) in ten-minute encounters in a neutral cage. Encounters were videotaped and behaviour evaluated, assigning times allocated by subjects to eleven broad behavioural categories. The data show that stress markedly decreases attack behaviour, but haloperidol does not protect against the disruptive action of immobilization. On the contrary, stress and haloperidol produced additive effects further decreasing attack and increasing immobility.
人们已经探究了抗精神病药物对抗应激对攻击行为的行为学影响的可能性。选用OF.1品系的雄性小鼠进行以下处理：1）固定应激（持续10或20分钟），2）氟哌啶醇（三种剂量），3）固定应激（10分钟）加氟哌啶醇。单独饲养的实验动物在一个中性笼子里与标准对手（无嗅觉动物）进行10分钟的对抗。对抗过程进行录像，并对行为进行评估，将实验对象分配到11个宽泛行为类别的时间记录下来。数据显示，应激显著降低攻击行为，但氟哌啶醇不能防止固定应激的破坏作用。相反，应激和氟哌啶醇产生相加效应，进一步降低攻击行为并增加不动时间。
