Liu Xiaoli, Liu Lanxiang, Wang Rui, Jia Xiaojiao, Liu Binbin, Ma Ning, Lu Qiang
Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China.
Department of Medical Imaging, The First Hospital of Qinhuangdao, Qinhuangdao, China.
Endocr Connect. 2021 Jun 11;10(6):599-606. doi: 10.1530/EC-21-0202.
We aimed to investigate early arteriosclerosis and its risk factors in populations with prediabetes and new-onset diabetes.
A total of 148 participants who did not have diabetes mellitus were assigned to three groups through an oral glucose tolerance test: the normal glucose tolerance (NGT) group; the impaired glucose regulation, also known as prediabetes group and the new-onset type 2 diabetes mellitus group. The insulin resistance index was assessed using the homeostatic model assessment of insulin resistance (HOMA-IR). An ELISA was used to determine the level of fibroblast growth factor 21 (FGF21). An arteriosclerosis detector was used to measure the brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI). The baPWV, ABI, and FGF21 were used to assess early arteriosclerosis.
Significant differences in age, systolic blood pressure (SBP), fasting plasma glucose (FPG), 2-h plasma glucose (2hPG), 2-h insulin (2hINS), and HOMA-IR were found between the NGT group and the prediabetes and new-onset diabetes groups. All of the above, except 2hINS, showed an increasing trend. Moreover, the FGF21 was higher in the new-onset diabetes group than in the NGT group. The baPWV was higher in the new-onset diabetes group than in the other two groups, but no significant difference was noted in the ABI. Age, SBP, diastolic blood pressure, FPG, 2hPG, and FGF21 were positively correlated with the baPWV. In addition, FPG, SBP, FGF21, and HOMA-IR were independent risk factors for the baPWV.
Patients with prediabetes and new-onset diabetes may have more significant early arteriosclerosis. The blood glucose level and insulin resistance index may be independent risk factors for early arteriosclerosis.
我们旨在研究糖尿病前期和新发糖尿病患者人群中的早期动脉硬化及其危险因素。
通过口服葡萄糖耐量试验，将总共148名无糖尿病的参与者分为三组：正常糖耐量（NGT）组；糖调节受损组，也称为糖尿病前期组和新发2型糖尿病组。使用胰岛素抵抗稳态模型评估（HOMA-IR）来评估胰岛素抵抗指数。采用酶联免疫吸附测定法（ELISA）测定成纤维细胞生长因子21（FGF21）水平。使用动脉硬化检测仪测量肱踝脉搏波速度（baPWV）和踝臂指数（ABI）。baPWV、ABI和FGF21用于评估早期动脉硬化。
NGT组与糖尿病前期组和新发糖尿病组在年龄、收缩压（SBP）、空腹血糖（FPG）、餐后2小时血糖（2hPG）、餐后2小时胰岛素（2hINS）和HOMA-IR方面存在显著差异。除2hINS外，上述所有指标均呈上升趋势。此外，新发糖尿病组的FGF21高于NGT组。新发糖尿病组的baPWV高于其他两组，但ABI无显著差异。年龄、SBP、舒张压、FPG、2hPG和FGF21与baPWV呈正相关。此外，FPG、SBP、FGF21和HOMA-IR是baPWV的独立危险因素。
糖尿病前期和新发糖尿病患者可能存在更显著的早期动脉硬化。血糖水平和胰岛素抵抗指数可能是早期动脉硬化的独立危险因素。
