Jiang Zhen-Zhen, Zhu Jian-Bo, Shen Hua-Liang, Zhao Shan-Shan, Tang Yun-Yi, Tang Shao-Qi, Liu Xia-Tian, Jiang Tian-An
Department of Ultrasound Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Ultrasound, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, China.
Front Cardiovasc Med. 2022 Mar 3;9:832491. doi: 10.3389/fcvm.2022.832491. eCollection 2022.
The triglyceride-glucose (TyG) index has been proposed as a convincing indicator of insulin resistance and has been found to be associated with atherosclerosis among diabetic patients. However, the relationship between the TyG index and arteriosclerosis in subjects with prediabetes and new-onset type 2 diabetes (T2D) remains uncertain. The purpose of this study was to assess the degree of carotid plaque burden in patients with prediabetes and new-onset T2D and to investigate the association between the TyG index and the degree of carotid plaque burden in this population.
This was a cross-sectional observational study that included 716 subjects aged 40-70 years old with prediabetes or new-onset T2D. Demographic, anthropometric, and laboratory measurements were collected. Participants underwent carotid arteriosclerosis evaluation by ultrasonography, and the degree of atherosclerosis was evaluated according to the carotid plaque burden. The TyG index was calculated.
The population was stratified into high or low TyG index groups according to the median TyG index value. Higher values were associated with a higher BMI and waist circumference as well as higher total cholesterol, triglyceride, low-density lipoprotein cholesterol, plasma glucose, glycated hemoglobin, fasting C-peptide, and C-reactive protein levels ( < 0.001). The high TyG index group had a higher atherosclerotic plaque burden than the low TyG index group ( < 0.001). Multiclassification logistic regression analysis showed that the TyG index was positively associated with a high plaque burden [odds ratio (OR): 16.706, 95% confidence interval (CI): 3.988-69.978, = 0.000], while no association was found between the TyG index and a low/moderate plaque burden. This association remained consistent in the subgroup analysis. In multiple linear regression analysis, sex, age, and the TyG index were found to be independently associated with carotid plaque burden. For each unit increase in the TyG index, the risk of a high carotid plaque burden increased 1.595-fold.
A high TyG index was positively associated with a high carotid plaque burden in subjects with prediabetes and new-onset T2D. Clinicians should pay close attention to the TyG index to help these patients receive the greatest benefit from early intervention.
甘油三酯-葡萄糖（TyG）指数已被提出作为胰岛素抵抗的一个有说服力的指标，并且已发现其与糖尿病患者的动脉粥样硬化有关。然而，TyG指数与糖尿病前期和新诊断的2型糖尿病（T2D）患者的动脉硬化之间的关系仍不明确。本研究的目的是评估糖尿病前期和新诊断的T2D患者的颈动脉斑块负荷程度，并探讨该人群中TyG指数与颈动脉斑块负荷程度之间的关联。
这是一项横断面观察性研究，纳入了716名年龄在40至70岁之间的糖尿病前期或新诊断的T2D患者。收集了人口统计学、人体测量学和实验室测量数据。参与者接受了颈动脉超声检查以评估动脉硬化情况，并根据颈动脉斑块负荷评估动脉粥样硬化程度。计算TyG指数。
根据TyG指数的中位数将人群分为高TyG指数组或低TyG指数组。较高的TyG指数值与较高的体重指数、腰围以及较高的总胆固醇、甘油三酯、低密度脂蛋白胆固醇、血糖、糖化血红蛋白、空腹C肽和C反应蛋白水平相关（<0.001）。高TyG指数组的动脉粥样硬化斑块负荷高于低TyG指数组（<0.001）。多分类逻辑回归分析显示，TyG指数与高斑块负荷呈正相关[比值比（OR）：16.706，95%置信区间（CI）：3.988 - 69.978，P = 0.000]，而未发现TyG指数与低/中度斑块负荷之间存在关联。在亚组分析中，这种关联仍然一致。在多元线性回归分析中，发现性别、年龄和TyG指数与颈动脉斑块负荷独立相关。TyG指数每增加一个单位，颈动脉高斑块负荷的风险增加1.595倍。
在糖尿病前期和新诊断的T2D患者中，高TyG指数与高颈动脉斑块负荷呈正相关。临床医生应密切关注TyG指数，以帮助这些患者从早期干预中获得最大益处。
