Medical Oncology, Department of Medicine, University of Verona Hospital Trust, Verona, Italy.
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Expert Rev Anticancer Ther. 2021 Aug;21(8):819-826. doi: 10.1080/14737140.2021.1927720. Epub 2021 May 27.
: Cachexia represents a relevant issue in oncological care, which is still lacking effective therapies. Although the incidence of cancer cachexia varies across cancer types, it is responsible for approximately a quarter of cancer-related deaths. The pathophysiology of this syndrome is multifactorial, including weight loss, muscle atrophy and impairment of the pro-/anti-inflammatory balance.: Diagnostic criteria and optimal endpoints for cachexia-dedicated trials are still debated, slowing the identification of interventions counteracting cachexia . The multifaceted features of this syndrome support the rationale for personalized therapy. A multimodal approach is likely to offer the best option to address key cachexia-related issues. Pharmacologic agents, physical exercise, nutritional and psycho-social interventions may have a synergistic effect, and improve quality of life.: A personalized multimodal intervention could be the best strategy to effectively manage cancer cachexia. To offer such a comprehensive approach, a specialized staff, including health professionals with different expertise, is necessary. Each specialist plays a specific role inside the multimodal intervention, with the aim of delivering the best cancer care and access to the most effective therapeutic options for each patient.
恶病质是肿瘤治疗中一个重要的问题，但目前仍缺乏有效的治疗方法。尽管不同类型的癌症恶病质的发病率不同，但它约占癌症相关死亡的四分之一。这种综合征的病理生理学是多因素的，包括体重减轻、肌肉萎缩和促炎/抗炎平衡受损。用于恶病质专门试验的诊断标准和最佳终点仍存在争议，这减缓了对抗恶病质干预措施的识别。这种综合征的多方面特征支持个性化治疗的合理性。多模式方法可能是解决关键恶病质相关问题的最佳选择。药物治疗、体育锻炼、营养和心理社会干预可能具有协同作用，并提高生活质量。个性化多模式干预可能是有效管理癌症恶病质的最佳策略。为了提供这种综合性的方法，需要有专门的工作人员，包括具有不同专业知识的卫生专业人员。每个专家在多模式干预中都扮演着特定的角色，目的是为每个患者提供最好的癌症护理和最有效的治疗选择。
