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阴道光滑念珠菌分离株对酿酒酵母产生的离子型杀毒素具有独特的敏感性。

Vaginal Isolates of Candida glabrata Are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae.

机构信息

Department of Biological Sciences, University of Idaho, Moscow, Idaho, USA.

Department of Internal Medicine, Division Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan, USA.

出版信息

Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0245020. doi: 10.1128/AAC.02450-20.

DOI:10.1128/AAC.02450-20
PMID:33972245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8218651/
Abstract

Compared to other species of yeasts, the growth of Candida glabrata is inhibited by many different strains of killer yeasts. The ionophoric K1 and K2 killer toxins are broadly inhibitory to all clinical isolates of C. glabrata from patients with recurrent vulvovaginal candidiasis, despite high levels of resistance to clinically relevant antifungal therapeutics.

摘要

与其他酵母物种相比，许多不同株的杀伤性酵母会抑制光滑球拟酵母的生长。亲脂性的 K1 和 K2 杀伤毒素对复发性外阴阴道念珠菌病患者的所有临床分离株的光滑球拟酵母均有广泛的抑制作用，尽管这些分离株对临床相关抗真菌治疗药物具有高水平的耐药性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06b/8218651/cb09f64223aa/aac.02450-20-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06b/8218651/79a16d2420eb/aac.02450-20-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06b/8218651/cb09f64223aa/aac.02450-20-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06b/8218651/79a16d2420eb/aac.02450-20-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06b/8218651/cb09f64223aa/aac.02450-20-f002.jpg

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